DIFFERENCES IN SYNAPTIC TRANSMISSION BETWEEN MEDIAL AND LATERAL COMPONENTS OF THE PERFORANT PATH
DIFFERENCES IN SYNAPTIC TRANSMISSION BETWEEN MEDIAL AND LATERAL COMPONENTS OF THE PERFORANT PATH
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DOI：
10.1016/0006-8993(84)91211-3
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
MCNAUGHTON, N
中科院分区：
文献类型：
--
作者：
ABRAHAM, WC;MCNAUGHTON, N
分别对内侧穿通径（MPP）和外侧穿通径（LPP）进行电击后，在齿状回门区记录到的电位之间的差异被归因于LPP电位电紧张传导至颗粒细胞胞体的树突较长。这一假设进行了测试，记录MPP和LPP诱发电位的门，在体内和体外制剂的分子层。在体内的场电位和电流源密度深度分布的分析表明，不同的波形不仅发生在门，但在分子层的突触接触的网站，以及。在体外研究中，成对的刺激和记录电极穿过分子层，并在距离细胞层约225 μ m处显示出相对突然的波形变化，预计MPP和LPP末端场之间的过渡区将位于该区域。 在分子层和门记录的电位之间的差异的定量分析表明，电子衰变占。MPP和LPP电位之间在门中观察到的差异为20%。这表明MPP和LPP门电位之间的差异主要是由于两条通路之间的突触传递性质的差异，而不是由于树突树上突触接触的不同部位。
The differences between the potentials recorded in the hilus of the dentate gyrus following test shocks applied separately to the medial perforant path (MPP) and the lateral perforant path (LPP) have been ascribed to the greater length of dendrite over which the LPP potentials are electrotonically conducted to the somata of the granule cells. This hypothesis was tested by recording MPP and LPP evoked potentials in the hilus, and in the molecular layer of both in vivo and in vitro preparations. Analysis of field potential and current source density depth profiles in vivo indicated that different waveshapes occurred not only in the hilus but at the sites of synaptic contact in the molecular layer as well. In the in vitro study, paired stimulating and recording electrodes were stepped through the molecular layer and revealed a relatively sudden waveshape change around 225 .mu.m from the cell layer, where the transitional zone between MPP and LPP terminal fields was expected to be located. Quantitative analysis of the differences between the potentials recorded in the molecular layer and the hilus revealed that electronic decay accounts for .apprx. 20% of the difference seen in the hilus between the MPP and LPP potentials. It is suggested that the differences between MPP and LPP hilar potentials are due mostly to differences between the 2 pathways in their properties of synaptic transmission, and are due relatively little to the different sites of synaptic contact on the dendritic tree.