EFFECTS OF CHANGES IN ALTITUDE ON HEMATOPOIETIC ACTIVITY
EFFECTS OF CHANGES IN ALTITUDE ON HEMATOPOIETIC ACTIVITY
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DOI：
10.1097/00005792-195109000-00001
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发表时间：
1951-01-01
期刊：
影响因子：
1.6
通讯作者：
HENNESSY, TG
中科院分区：
文献类型：
--
作者：
HUFF, RL;LAWRENCE, JH;HENNESSY, TG
受试者在接近海平面(利马)的基础条件下进行研究，然后在海拔14,900英尺的不同时间间隔(最长10天)后重新研究。(莫罗科查)。反向支出。在通常居住在Morococha的一个类似小组中进行了调查。总的来说，这群人从海平面移动到14,900英尺。结果显示，血红蛋白、HKT、红细胞和网织红细胞增加，血中%02饱和度降低，而正常停留在14,900英尺处的组发现相反的变化。当移动到海平面时。铁的周转率增加了2倍，居住地在14,900英尺。在为期10天的观察中。当高海拔原住民迁移到海平面时，铁的周转率线性下降到0.1，这是观察10天的控制值。在这一组中，观察到的细胞量的减少可以归因于产生率的下降和红细胞破坏率的增加。强调的是，所观察到的变化只在居住地改变后的10天内进行，在超过10天的时间内，红细胞产生速率发生进一步的重新调整。注意到的变化可能在12小时内不同程度地观察到。在换了住所之后。一组患有矽肺所致的严重红细胞增多症的Morococha原住民只在他们的正常居住地进行了研究。在这组患者中，可以观察到非常高的红细胞质量和减少的血浆体积。这组人的铁周转率过高，红细胞铁更新率高于正常人。
Subjects were studied under basal conditions at close to sea level (Lima) and then restudied after various time intervals of residence (up to 10 days) at an elevation of 14,900 ft. (Morococha). The reverse expt. was carried out in a similar group normally resident at Morococha. In general the group moving from sea level to 14,900 ft. showed an increase in hemoglobin, Hkt, erythrocytes, and reticulocytes and a decrease in % 02 saturation in blood, while opposite changes were found in the group normally resisent at 14,900 ft. when moved to sea level. Fe turnover rates increased by a factor of 2 with residence at 14,900 ft. during observations for 10 days. When high-altitude native were moved to sea level, Fe turnover rates fell linearly to 0.1, the control value in 10 days of observation. In this group the observed decrease in cell mass could be accounted for by a decreased production rate and presumably by an increased rate of red cell destruction. It is emphasized that changes ob -served were followed only over a 10-day period following change in residence and that during periods greater than 10 days further readjustment in rate of erythrocyte production occurs. The changes noted may be observed in varying degree within 12 hrs. after change in residence. A group of Morococha natives with severe polycythemia due to silicosis was studied only in their normal site of residence. In this group very high red cell masses and decreased plasma volumes were observed. Iron turnover rates in this group were excessively high and per cent of red cell Fe renewal was greater than in normal natives.