Long-term survival of a patient with small cell lung cancer associated with cancer-associated retinopathy
Long-term survival of a patient with small cell lung cancer associated with cancer-associated retinopathy
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DOI：
10.1016/j.lungcan.2007.02.015
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发表时间：
2007-09-01
期刊：
影响因子：
5.3
通讯作者：
Taguchi, Hirokuni
中科院分区：
文献类型：
--
作者：
Kobayashi, Makoto;Ikezoe, Takayuki;Taguchi, Hirokuni
癌症相关性视网膜病变（CAR）是一种罕见的副肿瘤性疾病，常见于小细胞肺癌（SCLC）患者;它是由针对23 kDa感光蛋白的自身抗体引起的。我们报告一个小细胞肺癌在同步放化疗后存活9年的病例。他的抗恢复素抗体仍呈阳性。SCLC长期生存而无复发可能与自身免疫机制有关，该机制由于抗恢复素抗体与视网膜细胞和肿瘤细胞交叉反应的存在而导致CAR。当前的文献综述旨在根据抗恢复蛋白抗体状态评估对总生存期的影响。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Cancer-associated retinopathy (CAR) is a rare paraneoplastic disorder that is frequently found in patients with small cell lung cancer (SCLC); it is caused by autoantibody to the 23-kDa photoreceptor protein, recoverin. We report a 9-year survivor of SCLC after concurrent chemoradiotherapy. His anti-recoverin antibody remains positive. Long-term survival without SCLC recurrence might be related to an autoimmunity mechanism that causes CAR due to the presence of anti-recoverin antibody cross-reacting with retinal cells and tumor cells. The current literature review was conducted to evaluate the impact on overall survival according to anti-recoverin antibody status. (c) 2007 Elsevier Ireland Ltd. All rights reserved.