Is Serous Cystadenoma of the Pancreas a Model of Clear-Cell-Associated Angiogenesis and Tumorigenesis?
Is Serous Cystadenoma of the Pancreas a Model of Clear-Cell-Associated Angiogenesis and Tumorigenesis?
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DOI：
10.1159/000178890
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发表时间：
2009-01-01
期刊：
影响因子：
3.6
通讯作者：
Adsay, N. Volkan
中科院分区：
文献类型：
--
作者：
Thirabanjasak, Duangpen;Basturk, Olca;Adsay, N. Volkan
背景：胰腺浆液性囊腺瘤类似于其他与von Hippel-Lindau(VHL)相关的肿瘤，如肾细胞癌和毛细血管母细胞瘤，也以透明细胞为特征。多年来，我们也注意到肿瘤上皮细胞显示出明显的毛细血管网络。方法：对18例SCA进行组织学复习，免疫组织化学方法检测CD31、血管内皮生长因子(VEGF)及与透明细胞肿瘤发生有关的分子GLUT-1、缺氧诱导因子-1α(HIF-1α)和碳酸酐酶IX(CA IX)的表达。结果：所有SCA均可见广泛丰富的毛细血管网，几乎位于上皮内，CD31染色证实，平均每100个上皮细胞有26个毛细血管。10/18例有血管内皮生长因子表达。在透明细胞肿瘤标志物中，CAIX在所有病例中均可检测到，GLUT-1和HIF-1α在大多数病例中均可检测到。结论：与其他VHL相关的透明细胞肿瘤一样，SCA上皮附近有一个突出的毛细血管网络，证实透明细胞-血管生成关系也适用于该类型的肿瘤。与透明细胞肿瘤发生有关的分子也在SCA中持续表达。这可能具有生物学和治疗意义，特别是考虑到针对这些途径的快速进化的药物。更重要的是，SCA也可能作为透明细胞相关血管生成和肿瘤发生的模型，从这种肿瘤类型中获得的信息也可能适用于其他透明细胞肿瘤。版权所有(C)2008 S.Karger AG，巴塞尔和IAP
Background: Similar to the other von Hippel-Lindau (VHL) related tumors such as renal cell carcinomas and capillary hemangioblastomas, serous cystadenomas (SCAs) of the pancreas are also characterized by clear cells. Over the years, we have also noticed that the tumor epithelium shows a prominent capillary network. Methods: Eighteen cases of SCA were reviewed histologically, and immunohistochemical analysis was performed for CD31 and vascular endothelial growth factor (VEGF) as well as the molecules implicated in clear-cell tumorigenesis: GLUT-1, hypoxia-inducible factor-1 (HIF-1 alpha), and carbonic anhydrase IX (CA IX). Results: There was an extensively rich capillary network that appears almost intraepithelially in all cases of SCA, which was confirmed by CD31 stain that showed, on average, 26 capillaries per every 100 epithelial cells. VEGF expression was identified in 10/18 cases. Among the clear-cell tumorigenesis markers, CA IX was detected in all cases, GLUT-1 and HIF-1 alpha in most cases. Conclusion: As in other VHL-related clear-cell tumors, there is a prominent capillary network immediately adjacent to the epithelium of SCA, confirming that the clear-cell-angiogenesis association is also valid for this tumor type. Molecules implicated in clear-cell tumorigenesis are also consistently expressed in SCA. This may have biologic and therapeutic implications, especially considering the rapidly evolving drugs against these pathways. More importantly, SCA may also serve as a model of clear-cell-associated angiogenesis and tumorigenesis, and the information gained from this tumor type may also be applicable to other clear-cell tumors. Copyright (C) 2008 S. Karger AG, Basel and IAP