Measurement and Correlation of the Solubility of Florfenicol Form A
Measurement and Correlation of the Solubility of Florfenicol Form A
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A 型氟苯尼考溶解度的测定和相关性
DOI：
10.1021/acs.jced.8b00043
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发表时间：
2018
影响因子：
--
通讯作者：
ren baozeng
中科院分区：
文献类型：
--
作者：
zhang pengshuai;zhangchi;zhaorui;wanyameng;yang zongkai;he ruyi;chen qiliang;li tao;ren baozeng
氟苯尼考A型在8种纯有机溶剂中的溶解度（丙酸、乙醇、1-丙醇、1-丁醇、2-丙醇、2-甲基-1-丙醇、3-甲基-1-丁醇和2-乙基-1-己醇）和三种二元溶剂（二甲基亚砜+乙醇，二甲基亚砜+ 1-丙醇，和二甲基亚砜+1-丁醇）在283.15 ~ 323.15K温度范围内进行了激光动态测量。实验结果表明，氟苯尼考在纯溶剂中的溶解度由大到小的顺序为：乙醇>正丙醇> 2-丙醇>正丁醇> 3-甲基-1-丁醇> 2-甲基-1-丙醇>丙酸> 2-乙基-1-己醇。实验结果表明，氟苯尼考晶型A在二元溶剂中的溶解度随温度和二甲亚砜质量分数的增加而增加。实验数据与修正的Apelblat方程、λ方程、NRTL模型方程和Wilson模型方程具有良好的相关性。在纯溶剂中，修正的Apelblat模型方程与实验值拟合最好。
The solubility of florfenicol form A in eight pure organic solvents (propionic acid, ethanol, 1-propanol, 1-butanol, 2-propanol, 2-methyl-1-propanol, 3-methyl-1-butanol, and 2-ethyl-1-hexanol) and three binary solvents (dimethyl sulfoxide + ethanol, dimethyl sulfoxide + 1-propanol, and dimethyl sulfoxide + 1-butanol) was measured by a laser dynamic method at temperature from 283.15 to 323.15 K. The experimental results show that the mole fraction solubility of florfenicol in the pure solvents decreased according to the following order: ethanol > 1-propanol > 2-propanol > 1-butanol > 3-methyl-1-butanol > 2-methyl-1-propanol ≈ propionic acid > 2-ethyl-1-hexanol. The experimental results show that the mole fraction solubility of florfenicol form A in the binary solvents increased with the increase of temperature and dimethyl sulfoxide mass fraction. The experimental solubility data were well correlated with the four thermodynamic models: modified Apelblat equation,λhequation, NRTL model equation, and Wilson model equation. The modified Apelblat model equation was regarded as the best one to fit the experimental values in the pure solvents.