DOSAGE-DEPENDENT MODIFIERS OF POLYCOMB AND ANTENNAPEDIA MUTATIONS IN DROSOPHILA
DOSAGE-DEPENDENT MODIFIERS OF POLYCOMB AND ANTENNAPEDIA MUTATIONS IN DROSOPHILA
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DOI：
10.1073/pnas.85.21.8136
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发表时间：
1988-11-01
影响因子：
11.1
通讯作者：
TAMKUN, JW
中科院分区：
文献类型：
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作者：
KENNISON, JA;TAMKUN, JW
已知在果蝇中控制体节身份确定的两个基因是Polycomb和Antenepedia。为了确定参与确定节段身份的其他基因，我们分离了polycomb和/或plannapedia突变的显性修饰子（抑制子和增强子）。64个这样的修饰突变已被恢复，并映射到18个互补组。所有的突变都能识别出受精卵生存所必需的基因。通过与Polycomb和/或Aprannapedia相互作用的突变鉴定的18个基因中的6个先前已被表征为同源异型基因[即，性梳减少（Scr）、Brista（Ba）、三胸（trx）、多梳（Pc）、多梳状（Pcl）和腿中部性梳（Scm）]。在这里确定的几个额外的基因座的突变也已被证明具有同源异型表型。
Two genes known to control the determination of segmental identity in Drosophila melanogaster are Polycomb and Antenepedia. To identify additional genes involved in the determination of segmental identity, we have isolated dominant modifers (both suppressors and enhancers) of polycomb and/or Antennapedia mutations. Sixty-four such modifier mutations have been recovered and mapped to 18 complementation groups. All of the mutations identify genes necessary for viability of the zygote. Six of the 18 genes that were identified by mutations that interact with Polycomb and/or Antennapedia have been previously characterized as homoeotic genes [i.e., Sex combs reduced (Scr), Brista (Ba), trithorax (trx), Polycomb (Pc), Polycomblike (Pcl), and Sex comb on midleg (Scm)]. Mutations in several of the additional loci identified here have also been shown to have homoeotic phenotypes.