PERSISTENT OXIDATIVE STRESS IN CANCER
PERSISTENT OXIDATIVE STRESS IN CANCER
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DOI：
10.1016/0014-5793(94)01368-b
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发表时间：
1995-01-16
期刊：
影响因子：
3.5
通讯作者：
HIAI, H
中科院分区：
文献类型：
--
作者：
TOYOKUNI, S;OKAMOTO, K;HIAI, H
癌组织如肾细胞癌和乳腺浸润性导管癌的DNA，持续暴露在比邻近正常组织更多的氧化应激下。我们认为，癌症中持续氧化应激的概念可能开辟一个新的研究领域，解释癌症特有的部分肿瘤生物学特征，如激活的转录因子和原癌基因、基因组不稳定性、化疗耐药、侵袭和转移。
DNA of cancers such as renal cell carcinoma and mammary invasive ductal carcinoma, is persistently exposed to more oxidative stress than that of adjacent nornal tissue. We suggest that the concept of 'persistent oxidative stress in cancer' may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto-oncogenes, genomic instability, chemotherapy-resistance, invasion and metastasis.