Mechanics of microtubules
Mechanics of microtubules
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DOI：
10.1016/j.jbiomech.2009.09.005
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发表时间：
2010-01-05
影响因子：
2.4
通讯作者：
Ross, Jennifer L.
中科院分区：
文献类型：
--
作者：
Hawkins, Taviare;Mirigian, Matthew;Ross, Jennifer L.
微管是刚性的细胞骨架细丝，其力学影响细胞形态和细胞过程。例如，微管为扩展形态的支持结构，如轴突和纤毛。此外，微管在细胞分裂过程中充当拉杆，将染色体拉开。与其他细胞骨架细丝（如肌动蛋白）不同，微管是单独或以小群体的形式工作的，因此它们的单个机械特性对它们的细胞功能非常重要。在这篇综述中，我们探讨了过去的工作对单个微管的机制，其中有。被研究了超过四分之一个世纪。我们还提出了未来努力确定控制微管刚性的分子机制的一些展望。Elsevier Ltd.出版。
Microtubules are rigid cytoskeletal filaments, and their mechanics affect cell morphology and cellular processes. For instance, microtubules for the support structures for extended morphologies, such as axons and cilia. Further, microtubules act as tension rods to pull apart chromosomes during cellular division. Unlike other cytoskeletal filaments (e.g., actin) that work as large networks, microtubules work individually or in small groups, so their individual mechanical properties are quite important to their cellular function. In this review, we explore the past work on the mechanics of individual microtubules, which have. been studied for over a quarter of a century. We also present some prospective on future endeavors to determine the molecular mechanisms that control microtubule rigidity. Published by Elsevier Ltd.