Caffeine-related effects on cognitive performance: Roles of apoptosis in rat hippocampus following sleep deprivation
Caffeine-related effects on cognitive performance: Roles of apoptosis in rat hippocampus following sleep deprivation
复制标题
咖啡因对认知能力的相关影响：睡眠剥夺后大鼠海马细胞凋亡的作用
DOI：
10.1016/j.bbrc.2020.11.029
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发表时间：
2021-01-01
影响因子：
3.1
通讯作者：
Huang, Panpan
中科院分区：
文献类型：
--
作者：
Xie, Guangjing;Huang, Xiaoyu;Huang, Panpan
咖啡因是一种常见的兴奋剂，广泛存在于食物中，对中枢神经系统有刺激作用，轮班工作的人经常依靠咖啡因来保持注意力和清醒。虽然睡眠剥夺（SD）被广泛认为是认知障碍的独立危险因素，但咖啡因剂量和SD对认知能力的协同作用知之甚少。本研究旨在探讨不同咖啡因剂量对睡眠剥夺后认知功能的潜在分子机制。结果显示，SD可减轻认知功能障碍，并伴有海马超微结构损伤和锥体神经元丢失，降低VIP和AVP水平。SD还显著加速了海马神经肽相关的凋亡，这可能是通过cAMP-PKA-CREB信号通路轴和下游凋亡基因的激活来调节的。此外，数据表明，低剂量咖啡因（LC）有助于认知增强，高剂量咖啡因（HC）通过调节海马神经元凋亡加重认知障碍。我们的研究表明，咖啡因，特别是高剂量的咖啡因，可能是影响睡眠不足引起的神经认知结果的潜在因素，睡眠剥夺后摄入适量的咖啡因值得认真考虑。(C) 2020爱思唯尔公司版权所有。
Caffeine is a common stimulant widely existed in food and has stimulatory effects on the central nervous system, shift-work individuals often rely on caffeine to maintain attention and keep awake. Although sleep deprivation (SD) is widely considered as an independent risk factor for cognition retardations, however, little is well understood about the synergistic role of caffeine dosage and SD for cognitive performance. This research intended to investigate the underlying molecular mechanism of varying caffeine doses on cognitive function after sleep deprivation. The results revealed that SD attenuated the cognitive dysfunction, associated with ultrastructure damage and pyramidal neuron loss in the hippocampus, decreased in the level of VIP and AVP. SD also significantly accelerated the neuropeptide-associated apoptosis in the hippocampus, which may modulate via the cAMP-PKA-CREB signal path axis and activation of the downstream apoptosis genes. Additionally, the data indicated that low-dose caffeine (LC) contributed to cognitive enhancement, and high-dose caffeine (HC) aggravated cognitive impairment by modulating hippocampal neuronal apoptosis. Our studies suggest that caffeine, particularly in high dosage, may be a potential factor to influence the neurocognitive outcome caused by sleep loss, and the appropriate amount of caffeine ingested after sleep deprivation deserves serious consideration. (C) 2020 Elsevier Inc. All rights reserved.