Plasma adrenomedullin levels in patients with non-insulin dependent diabetes mellitus: close relationships with diabetic complications.
Plasma adrenomedullin levels in patients with non-insulin dependent diabetes mellitus: close relationships with diabetic complications.
复制标题
非胰岛素依赖型糖尿病患者的血浆肾上腺髓质素水平：与糖尿病并发症的密切关系。
DOI：
10.1507/endocrj.45.241
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发表时间：
1998
影响因子：
2
通讯作者：
Toshikazu Saito
中科院分区：
文献类型：
--
作者：
Tomoatsu Nakamura;K. Honda;S. Ishikawa;K. Kitamura;T. Eto;Toshikazu Saito
本研究旨在检测非胰岛素依赖型糖尿病（NIDDM）患者血浆肾上腺髓质素水平，以阐明其可能参与糖尿病并发症的发病机制。男性24例，女性21例，年龄55 +/- 2.1岁（平均+/- SEM）。NIDDM患者血浆肾上腺髓质素水平为5.94 +/- 0.44 pmol/l，不受血浆葡萄糖浓度的影响。血浆肾上腺髓质素的升高依赖于糖尿病肾病和视网膜病变的严重程度。血浆肾上腺髓质素水平与血清肌酐水平、尿蛋白排泄、收缩压等参数呈正相关。RR间隔变异系数（CV）与血浆肾上腺髓质素呈负相关，尺神经传导速度与血浆肾上腺髓质素呈负相关。提示血浆肾上腺髓质素升高与糖尿病并发症密切相关，可能依赖于微血管病变的发展。
The present study was undertaken to determine plasma adrenomedullin levels in patients with non-insulin dependent diabetes mellitus (NIDDM) to elucidate the potential involvement in the pathogenesis of diabetic complications. The patients were 24 males and 21 females with ages of 55 +/- 2.1 years (mean +/- SEM). Plasma adrenomedullin levels were 5.94 +/- 0.44 pmol/l in patients with NIDDM, and were not affected by plasma glucose concentration. The plasma adrenomedullin increased dependent on the severity of diabetic nephropathy and retinopathy. Plasma levels of adrenomedullin positively correlated with various parameters, including serum creatinine levels, urinary excretion of protein, and systolic blood pressure. In contrast, there were negative correlations between the coefficient variation (CV) of RR intervals and plasma adrenomedullin, and between the conduction velocity of ulnar nerves and plasma adrenomedullin levels. These results indicate that the increase in plasma adrenomedullin was closely related to diabetic complications, which may be dependent on the development of microangiopathy.