Saffold Cardiovirus Infection in Children Associated With Respiratory Disease and Its Similarity to Coxsackievirus Infection
Saffold Cardiovirus Infection in Children Associated With Respiratory Disease and Its Similarity to Coxsackievirus Infection
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DOI：
10.1097/inf.0b013e31821608a8
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发表时间：
2011-08-11
影响因子：
3.6
通讯作者：
Matsuzaki, Yoko
中科院分区：
文献类型：
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作者：
Itagaki, Tsutomu;Abiko, Chieko;Matsuzaki, Yoko
背景：红花病毒（SAFV）是一种新发现的小核糖核酸病毒科红花病毒属病毒。使用分子技术，SAFV已被检测到，虽然很少，在健康和腹泻儿童的粪便和呼吸道疾病的儿童收集的呼吸道标本。方法：收集2009年7月至2010年10月间我院收治的急性呼吸道感染患儿鼻咽部标本。收集的样本用于分离呼吸道病毒，包括柯萨奇病毒，通过细胞培养和检测SAFV通过逆转录-聚合酶链反应。结果：54（3.5%）检测1525名儿童的SAFV基因型2（SAFV 2）。SAFV 2的检测显示了4个月的流行模式，在2009年10月达到高峰。SAFV 2阳性儿童的中位年龄为4岁（范围：7个月-16岁）。在35例SAFV 2阳性儿童中，排除病毒合并感染的病例，13例（37.1%）患有咽炎，12例（34.3%）患有扁桃体炎，8例（22.8%）患有疱疹性咽峡炎。支气管炎和胃肠炎各1例。33例（94.3%）病例出现发热（体温> 38 ℃）。中位发热持续时间为2天（范围：1-3天）。腹泻7例（20.0%），但水样腹泻和频繁腹泻并不常见。SAFV 2感染的年龄分布和临床诊断与柯萨奇病毒B4感染相似，在研究期间，检测显示流行模式。结论：SAFV 2是上呼吸道疾病的原因，表现出与柯萨奇病毒B相似的致病性。
Background: Saffold virus (SAFV) is a newly discovered virus belonging to the genus Cardiovirus of the family Picornaviridae. Using molecular techniques, SAFV has been detected, although infrequently, in the stools of both healthy and diarrheic children and in respiratory specimens collected from children with respiratory disease. The epidemiology and pathogenicity of SAFV remain unclear.Methods: Between July 2009 and October 2010, nasopharyngeal specimens were collected from children with acute respiratory infections. The collected samples were used to isolate respiratory viruses, including coxsackievirus, by cell culture and were tested for SAFV by reverse transcription-polymerase chain reaction.Results: SAFV genotype 2 (SAFV2) was detected in 54 (3.5%) of the 1525 children tested. SAFV2 detections showed an epidemic pattern for a 4-month period with a peak in October 2009. The median age of the SAFV2-positive children was 4 years (range: 7 months-16 years). Among the 35 SAFV2-positive children, excluding cases of viral coinfection, 13 (37.1%) had pharyngitis, 12 (34.3%) had tonsillitis, and 8 (22.8%) had herpangina. Bronchitis and gastroenteritis were detected in 1 case each. Fever (temperature, > 38 degrees C) was noted in 33 (94.3%) cases. The median duration of fever was 2 days (range: 1-3 days). Diarrhea was observed in 7 (20.0%) children, but watery and frequent diarrhea was not common. The age distribution and clinical diagnoses associated with SAFV2 infections were similar to those observed with coxsackievirus B4 infections, which detections showed an epidemic pattern during the study period.Conclusion: SAFV2 is a cause of upper respiratory tract illness that exhibits a pathogenicity similar to that of coxsackievirus B.