The effects of depressive symptoms on cardiovascular and catecholamine responses to the induction of depressive mood
The effects of depressive symptoms on cardiovascular and catecholamine responses to the induction of depressive mood
复制标题
DOI：
10.1016/j.biopsycho.2006.06.003
复制
发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Steptoe, Andrew
中科院分区：
文献类型：
--
作者：
Hamer, Mark;Tanaka, Gohichi;Steptoe, Andrew
我们研究了抑郁症状对心血管和儿茶酚胺反应的影响，以诱导不同的情绪状态。招募了55名健康男性和女性（平均年龄23.4 ± 3岁）。使用流行病学研究中心抑郁量表（CES-D）评估抑郁症状，并将参与者分为高抑郁（CES-D* 16）或低抑郁症状（CES-D < 16）组。在基线期之后，参与者被要求完成两个独立的语音任务，要求他们回忆让他们感到愤怒或沮丧的生活事件。这些任务被30分钟的恢复期分开，并且使用平衡设计在参与者之间随机分配顺序。使用Finometer装置连续监测心血管功能，并收集唾液用于评估3-甲氧基-苯乙二醇（MHPG，去甲肾上腺素的主要代谢物）。血压（BP）、心率和总外周阻力（TPR）在两项任务中均显著增加（p = 0.001）。在高抑郁症状参与者中观察到平均条件下，较高的舒张压和较高的MHPG水平。在低抑郁症状组中，MHPG水平对情绪诱导没有反应。然而，高抑郁症状组表现出显着较高的水平MHPG从抑郁情绪诱导任务的恢复和愤怒诱导任务后立即增加的水平。这些研究结果表明，抑郁症状与负面情绪诱导过程中中枢肾上腺素能激活增强有关，但反应的时间过程取决于引发的情绪类型。(c)2006 Elsevier B. V.保留所有权利。
We examined the effects of depressive symptoms on cardiovascular and catecholamine responses to the induction of different mood states. Fifty-five healthy men and women (mean age 23.4 +/- 3 years) were recruited. Depressive symptoms were evaluated using the Center for Epidemiological Studies Depression Scale (CES-D) and participants were classified into high depressive (CES-D* 16) or low depressive symptoms (CES-D < 16) groups. Following a baseline period, participants were required to complete two separate speech tasks where they were asked to recall life events that made them feel angry or depressed. The tasks were separated by a 30-min recovery period and the order was randomised between participants using a counterbalanced design. Cardiovascular function was monitored continuously using a Finometer device and saliva was collected for the assessment of 3-methoxy-phenylglycol (MHPG, the major metabolite of norephinephrine). Blood pressure (BP), heart rate, and total peripheral resistance (TPR) were significantly increased in response to both tasks (p =.001). Averaged over conditions, higher diastolic BP and higher MHPG levels were observed in high depressive symptoms participants. MHPG levels did not change in response to mood induction in the low depressive symptoms group. However, the high depression symptoms group showed significantly higher levels of MHPG during recovery from the depressed mood induction task and increased levels immediately after the anger induction task. These findings suggest depressive symptoms are associated with heightened central adrenergic activation during negative mood induction, but that the time course of responses is dependent on the type of emotion elicited. (c) 2006 Elsevier B.V. All rights reserved.