Estimation of absorbed dose in cell nuclei due to DNA-bound 3H.
Estimation of absorbed dose in cell nuclei due to DNA-bound 3H.
复制标题
估计由于 DNA 结合 3H 导致的细胞核吸收剂量。
DOI：
10.1097/00004032-198504000-00009
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发表时间：
1985
期刊：
影响因子：
2.2
通讯作者：
M. Molls
中科院分区：
文献类型：
--
作者：
M. Saito;M. Ishida;C. Streffer;M. Molls
用Monte Carlo方法模拟了一个球形模型细胞核的DNA结合~ 3 H的吸收剂量。发现细胞核的形状在确定平均吸收剂量方面不太重要。对于具有相同DNA含量和相同DNA比活性的细胞核，细胞核的体积是主要的剂量决定因素。将该结果应用于妊娠期饮水摄入3 H-胸苷的母鼠所生幼鼠器官细胞核中的累积剂量估计。对于各种器官，与假定的3 H在器官中均匀分布的剂量相比，DNA结合3 H的累积剂量的剂量修正因子的值在约2和6之间。
The average absorbed dose due to DNA-bound 3H in a cell nucleus was estimated by a Monte Carlo simulation for a model nucleus which was assumed to be spheroidal. The shape of the cell nucleus was found to be of minor importance in determining the average absorbed dose. The volume of the cell nucleus was the major dose-determining factor for cell nuclei which have the same DNA content and the same specific activity of DNA. This result was applied to estimating the accumulated dose in the cell nuclei of organs of young mice born from mother mice which ingested 3H-thymidine with drinking water during pregnancy. The values of dose-modifying factors for the accumulated dose due to DNA-bound 3H compared to the dose due to an assumed homogenous distribution of 3H in organ were found to be between about 2 and 6 for the various organs.