Effect of Existence of Red Blood Cells in Trapping Performance of Microbubbles by Acoustic Radiation Force
Effect of Existence of Red Blood Cells in Trapping Performance of Microbubbles by Acoustic Radiation Force
复制标题
红细胞的存在对声辐射力捕获微泡性能的影响
DOI：
10.1143/jjap.50.07hf11
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发表时间：
2011
影响因子：
1.5
通讯作者：
T. Chiba
中科院分区：
文献类型：
--
作者：
K. Masuda;Ryusuke Nakamoto;N. Watarai;R. Koda;Y. Taguchi;T. Kozuka;Y. Miyamoto;T. Kakimoto;S. Enosawa;T. Chiba
我们提出了一种利用声传播产生的声辐射力来控制微泡的方法，以对应超声波的治疗应用。通过防止气泡穿过所需的目标区域，可以增强气泡的局部浓度。然而，我们从未在体内或接近体内条件下通过实验证实这种现象。因此，我们进行了一项实验，以评估使用红细胞（RBC）悬浮液和人造血管的气泡捕获性能。通过定义捕获指数来评估捕获的微泡的量，我们证实捕获性能是根据红细胞浓度和声压增强的，而不是根据超声中心频率增强的。结果表明，微泡附近红细胞的存在导致了推向血管壁的聚集体尺寸的增加。
We have proposed a method to control microbubbles by making use of acoustic radiation force, which is generated with acoustic propagation, to correspond to therapeutic applications of ultrasound. By preventing bubbles from passing through the desired target area, the local concentration of bubbles can be enhanced. However, we have never experimentally confirmed this phenomenon under in vivo conditions or close to those. Thus, we carried out an experiment to evaluate the trapping performance of bubbles using a suspension of red blood cells (RBCs) and an artificial blood vessel. By defining the trapping index to evaluate the amount of trapped microbubbles, we have confirmed that the trapping performance was enhanced according to the concentration of RBCs and the sound pressure, but not according to the central frequency of ultrasound. The results indicate that the existence of RBCs near microbubbles contributed to the increase in the size of aggregations propelled against the vessel wall.
影响因子：
2.9
作者：
Dayton, P;Klibanov, A;Ferrara, K
通讯作者：
Ferrara, K