Placenta weight in pre-eclampsia
Placenta weight in pre-eclampsia
复制标题
DOI：
10.1080/00016340802056178
复制
发表时间：
2008-01-01
影响因子：
4.3
通讯作者：
Eskild, Anne
中科院分区：
文献类型：
--
作者：
Dahlstrom, Berit;Romundstad, Pal;Eskild, Anne
Objective.早产儿和足月儿先兆子痫的病因可能不同。这可能反映在胎盘重量的差异上。因此，我们比较了患有早产或足月先兆子痫的孕妇的胎盘重量与没有先兆子痫的孕妇的胎盘重量。设计人口研究。设置.挪威医学出生登记处。人口1999年至2004年，挪威所有单胎妊娠均在妊娠21周或21周后分娩（n = 317 688）。方法.将未患先兆子痫的孕妇的胎盘重量（n = 304，875）与患有早产先兆子痫（妊娠37周前分娩，n = 3，070）和足月先兆子痫（妊娠37周或之后分娩，n = 9，743）的孕妇的胎盘重量进行比较。计算胎盘重量z评分，以调整后代性别和妊娠时间，并按十分之一分组。根据先兆子痫状态的胎盘重量以每十分之一内的比例表示。主要结果指标。先兆子痫状态。结果在早产先兆子痫中，胎盘在两个最低的（33.8%; 95% CI 32.1-35.5）和两个最高的（13.1%）中代表性过高。95% CI 11.9-14.3）胎盘重量的十分之一，与无先兆子痫的妊娠（20%）相比。在足月先兆子痫中，胎盘在两个最低（22.0%; 95% CI 21.2-22.8）和两个最高（22.7%; 95% CI 21.9-23.6）胎盘重量组中的比例过高。与无先兆子痫的妊娠相比，足月先兆子痫的平均胎盘重量z评分更高。结论.小胎盘与先兆子痫相关，与早产儿的相关性比与足月先兆子痫的相关性更强。在足月子痫前期中，与胎盘重量的相关性呈u形，与无子痫前期的妊娠相比，胎盘重量低和高的比例更高。
Objective. Preterm and term pre-eclampsia may differ in etiology. This could be reflected in differences in placenta weight. Therefore, we compared placenta weight in pregnancies with preterm or term pre-eclampsia to placenta weight in pregnancies without pre-eclampsia. Design. Population study. Setting. Medical Birth Registry of Norway. Population. All singleton pregnancies in Norway from 1999 through 2004 delivered at or after 21 weeks' gestation (n =317,688). Methods. Placenta weight in pregnancies without pre-eclampsia (n =304,875) was compared to placenta weight in pregnancies with preterm pre-eclampsia (delivery before week 37 of pregnancy, n =3,070) and term pre-eclampsia (delivery on or after week 37 of pregnancy, n =9,743). Placenta weight z-scores were calculated to adjust for offspring sex and length of gestation, and grouped in tenths. Placenta weight according to pre-eclampsia status is presented as proportions within each tenth. Main outcome measures. Pre-eclampsia status. Results. In preterm pre-eclampsia, placentas were over-represented in the two lowest (33.8%; 95% CI 32.1-35.5) and under-represented in the two highest (13.1%. 95% CI 11.9-14.3) tenths of placenta weight compared to pregnancies without pre-eclampsia (20%). In term pre-eclampsia, placentas were over-represented in the two lowest (22.0%; 95% CI 21.2-22.8) and the two highest (22.7%; 95% CI 21.9-23.6) placenta weight groups. Mean placenta weight z-score was higher in term pre-eclampsia compared to pregnancies without pre-eclampsia. Conclusions. Small placentas were associated with pre-eclampsia, and more strongly with preterm than term pre-eclampsia. In term pre-eclampsia, the association with placenta weight was u-shaped, yielding higher proportions of both low and high placenta weight compared to pregnancies without pre-eclampsia.