Plasma linoleic acid partially mediates the association of bipolar disorder on self-reported mental health scales
Plasma linoleic acid partially mediates the association of bipolar disorder on self-reported mental health scales
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DOI：
10.1016/j.jpsychires.2015.06.001
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发表时间：
2015-09-01
影响因子：
4.8
通讯作者：
McInnis, Melvin G.
中科院分区：
文献类型：
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作者：
Evans, Simon J.;Assari, Shervin;McInnis, Melvin G.
我们已经表明，双相情感障碍患者的饮食质量降低，包括摄入较少的多不饱和脂肪酸（PUFA）。我们也报道了双相患者血浆中n-6 PUFA、亚油酸（LA）和n-3 PUFA、二十碳五烯酸（EPA）水平的降低。在当前的分析中，我们假设LA和EPA血浆水平会介导双相情感障碍受试者自我报告的心理健康和生活功能得分降低。在一项横断面研究中，我们收集了双相情感障碍患者（n = 56）和对照组（n = 46）的7天饮食记录，然后进行空腹抽血。我们使用结构方程建模路径分析来检验饮食摄入和血浆LA和EPA水平对自我报告的心理健康问卷得分的中介作用，包括生活功能问卷（LFQ）、患者健康问卷（PHQ9）和简短健康调查（SF12），提取心理健康成分总结得分（SF12- mm）。我们调整了年龄、性别、精神药物使用、身体质量指数（BMI）和总热量摄入作为双相情感障碍的协变量作为主要预测因子。我们发现双相情感障碍与较低的血浆LA水平之间存在显著的路径关联（p = 0.03），血浆LA与PHQ9 （p = 0.05）、LFQ （p = 0.01）和SF12-MH （p = 0.05）评分之间存在显著的路径关联，因此较低的血浆LA预示着较差的预后。我们没有发现血浆EPA水平与任何结果测量之间的显著关系。这些发现表明，血浆LA水平部分介导双相情感障碍对自我报告的心理健康和生活功能的影响。Elsevier Ltd.出版。
We have shown that bipolar individuals have reduced quality diets, including lower intake of polyunsaturated fatty acids (PUFA). We have also reported reduced plasma levels of the n-6 PUFA, linoleic acid (LA), and the n-3 PUFA, eicosapentaenoic acid (EPA) in bipolar subjects. In the current analysis we hypothesized that LA and EPA plasma levels would mediate lower self-reported mental health and life functioning scores in bipolar subjects. In a cross-sectional study, we collected a 7-day diet record in bipolar (n = 56) and control subjects (n = 46) followed by a fasted blood draw. We used structured equation modeling path analysis to test for mediating effects of dietary intake and plasma levels of LA and EPA on self-reported mental health questionnaire scores, including the Life Functioning Questionnaire (LFQ), the Patient Health Questionnaire (PHQ9), and the Short Form Health Survey (SF12), extracting the mental health component summary score (SF12-MM). We adjusted for age, gender, psychiatric medication use, body mass index (BMI), and total caloric intake as covariates with bipolar disorder as the primary predictor. We found a significant path association from bipolar disorder to lower plasma LA levels (p = 0.03) and significant paths from plasma LA to PHQ9 (p = 0.05), LFQ (p = 0.01) and SF12-MH (p = 0.05) scores, such that lower plasma LA predicted worse outcomes. We found no significant paths from plasma EPA levels to any of the outcome measures. These findings suggest that plasma LA levels partially mediate the effect of bipolar disorder on self-reported measures of mental health and life functioning. Published by Elsevier Ltd.