Dynamics of naive and memory CD4+ T lymphocytes in HIV-1 disease progression
Dynamics of naive and memory CD4+ T lymphocytes in HIV-1 disease progression
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DOI：
10.1097/00042560-200205010-00006
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发表时间：
2002-05-01
期刊：
影响因子：
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通讯作者：
Kirschner, D
中科院分区：
文献类型：
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作者：
Bajaria, SH;Webb, G;Kirschner, D
了解初始和记忆 CD4(+) T 细胞在 HIV-1 感染免疫反应中的动态有助于阐明在 HIV-1 患者中观察到的典型疾病进展模式。尽管在患者血液中监测CD4(+) T细胞计数和病毒载量等感染标志物，但淋巴组织(LT)已被证明是重要的病毒库。在这里，我们介绍了第一个基于 T 细胞亚群和 LT 和血液两个区室之间循环的病毒的疾病进展综合理论模型。我们使用该模型来预测在成人 HIV-1 疾病进展中观察到的几个特征，例如在无症状阶段建立设定点。我们的模型预测宿主和病毒元件在确定不同的疾病进展模式中发挥作用。病毒因素包括病毒感染性和生产率，而宿主因素包括特异性免疫因素。我们还预测了高效抗逆转录病毒治疗和治疗停止对血液和 LT 中细胞和病毒动态的影响。
Understanding the dynamics of naive and memory CD4(+) T cells in the immune response to HIV-1 infection can help elucidate typical disease progression patterns observed in HIV-1 patients. Although infection markers such as CD4(+) T-cell count and viral load are monitored in patient blood, the lymphatic tissues (LT) have been shown to be an important viral reservoir. Here, we introduce the first comprehensive theoretical model of disease progression based on T-cell subsets and virus circulating between the two compartments of LT and blood. We use this model to predict several trademarks observed in adult HIV-1 disease progression such as the establishment of a setpoint in the asymptomatic stage. Our model predicts that both host and viral elements play a role in determining different disease progression patterns. Viral factors include viral infectivity and production rates, whereas host factors include elements of specific immunity. We also predict the effect of highly active antiretroviral therapy and treatment cessation on cellular and viral dynamics in both blood and LT.