Cytokines and the nervous system: I. Expression and recognition
Cytokines and the nervous system: I. Expression and recognition
复制标题
DOI：
10.1016/0166-2236(95)93881-w
复制
发表时间：
1995-01-01
影响因子：
15.9
通讯作者：
Rothwell, Nancy J.
中科院分区：
文献类型：
--
作者：
Hopkins, Stephen J.;Rothwell, Nancy J.
细胞因子是一组异质性的多肽介导物，其典型地被认为与免疫系统和炎症反应的激活有关。越来越多的相关介质现在被包括在这一类别中，其中大多数已被证明作用于各种组织，包括PNS和CNS。细胞因子及其受体在这些神经系统的组织中表达，并且可能来源于入侵的免疫细胞或常驻细胞。外周组织的创伤也可能通过脑内的循环或继发性传导在中枢神经系统中诱发神经递质介导的事件。本文综述了这些神经递质的一般性质、表达和识别。
Cytokines are a heterogeneous group of polypeptide mediators that have been aswciakd classically wlth activation of the lmmune system and inflammatory responses. An incmasing number of related mediators is now included in this category and most of them have been shown to act on a variety of tissues, including the PNS and CNS. Cytokines and their recep tars are expressed in tissues of these nervous systems, and might derive from invading immune, or resident, cells. Trauma in peripheral tissues might also induce cytoklne-mediated events in the CNS, via either the circulation or secondary lnductlon wlthin the brain, In this first of a two= part review, the general properties, expression and recognition of these cytoklnes with respect to the nervous system are discussed.