Interactions between vasopressin and atrial natriuretic peptides.
Interactions between vasopressin and atrial natriuretic peptides.
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加压素和心房钠尿肽之间的相互作用。
DOI：
10.1111/j.1749-6632.1993.tb55565.x
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发表时间：
1993
影响因子：
5.2
通讯作者：
Ramsay,DJ
中科院分区：
文献类型：
--
作者：
Thrasher,TN;Ramsay,DJ
心房利钠肽（atrial natriuretic peptides，ANP）是一种肽家族，最初从心房组织中分离出来，但现在已在心室和脑中的多个部位发现。表征ANP作用的最初研究是基于微克量的材料的急性注射。这些研究表明，ANP是一种有效的利尿剂和利钠剂，同时也引起平均动脉压（MAP）降低，而不会引起心率反射性增加。这种作用的结合，再加上ANP向血浆中的内源性释放主要受心房压力控制的事实，迅速导致了ANP参与体液平衡的生理调节的概念。本章的目的是审查有关的证据心钠素水平的机制控制体液，主要强调心钠素和机制之间的相互作用，控制血浆精氨酸加压素（AVP），血浆肾素活性（PRA），和水的摄入量。
Atrial natriuretic peptides (ANP) are a family ofpeptides, which were originally isolated from atrial tissue but have now been found in the cardiac ventricles and various locations in the brain. lJ The initial studies that characterized the effects of ANP were based on acute injections of microgram quantities of material. These studies indicated that ANP was a potent diuretic and natriuretic agent and also caused a simultaneous reduction in mean arterial pressure (MAP) without a reflex increase in heart rate.'This combination of actions, together with the fact that endogenous release of ANP into plasma is primarily controlled by atrial pres~ ure,~'~ quickly led to the concept that ANP was involved in the physiological regulation of body fluid balance. The purpose of this chapter is to review the evidence relating ANP levels to mechanisms controlling body fluids, with the primary emphasis on interactions between ANP and mechanisms that control plasma arginine vasopressin (AVP), plasma renin activity (PRA), and water intake.