The design of organometallic ruthenium arene anticancer agents
The design of organometallic ruthenium arene anticancer agents
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DOI：
10.2533/chimia.2007.704
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发表时间：
2007-01-01
期刊：
影响因子：
1.2
通讯作者：
Sadler, Peter J.
中科院分区：
文献类型：
--
作者：
Dougan, Sarah J.;Sadler, Peter J.
Organometallic half-sandwich Ru-II anticancer complexes of the type [(eta(6)-arene)Ru(yZ)X](n) can exhibit interesting anticancer activity. We review the comparative aqueous solution chemistry (hydrolysis rates, pKa values of aqua complexes), cancer cell cytotoxicities, cross-resistance, reactivity towards nucleobases, DNA and important biomolecules for complexes containing various arenes, N,N- or N,O- or O,O-chelating ligands as YZ, and monodentate leaving groups X. We show that the choice of these ligands can have a dramatic effect on reactivity. The same is true for analogous Os-II arene complexes. The interpretation of structure-activity relationships requires an understanding of reactions of these organometallic complexes under biological test conditions.
