Clickity-click: highly functionalized peptoid oligomers generated by sequential conjugation reactions on solid-phase support
Clickity-click: highly functionalized peptoid oligomers generated by sequential conjugation reactions on solid-phase support
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DOI：
10.1039/b518247f
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Kirshenbaum, K
中科院分区：
文献类型：
--
作者：
Holub, JM;Jang, HJ;Kirshenbaum, K
N-取代的甘氨酸类肽低聚物用作叠氮化物-炔[ 3 + 2]环加成缀合反应的底物，然后通过另外几轮的低聚和环加成进行加工。这种新的连续缀合技术允许产生复杂的肽模拟物产物，其中多个异质侧基沿寡聚物支架沿着位点特异性定位。水溶性的雌二醇-二茂铁类肽共轭物的研究表明，模块化合成的生物传感器的潜在应用。
N-Substituted glycine peptoid oligomers were used as substrates for azide-alkyne [ 3 + 2] cycloaddition conjugation reactions and then elaborated through additional rounds of oligomerization and cycloaddition. This novel sequential conjugation technique allowed for the generation of complex peptidomimetic products in which multiple heterogeneous pendant groups were site-specifically positioned along the oligomer scaffold. Studies of a water-soluble estradiol-ferrocene peptoid conjugate demonstrated a potential application for the modular synthesis of biosensors.