Lactulose/mannitol test and specificity, sensitivity, and area under curve of intestinal permeability parameters in patients with liver cirrhosis and Crohn's disease
Lactulose/mannitol test and specificity, sensitivity, and area under curve of intestinal permeability parameters in patients with liver cirrhosis and Crohn's disease
复制标题
DOI：
10.1007/s10620-007-0184-8
复制
发表时间：
2008-10-01
影响因子：
3.1
通讯作者：
Cihalova, J.
中科院分区：
文献类型：
--
作者：
Dastych, Milan;Dastych, Milan, Jr.;Cihalova, J.
本研究的目的是研究和比较乳果糖/甘露醇比、乳果糖/肌酐比和乳果糖回收率的特异性、灵敏度和曲线下面积（AUC），以及它们在乳果糖/甘露醇（L/M）吸收试验中对肠道通透性评估的诊断价值。结果乳果糖/甘露醇比值、乳果糖/肌酐比值及乳果糖回收率在克罗恩病中的价值（0.0763 +/- 0.0369; 99.62 +/- 67.87; 1.0478 +/- 0.6148）和肝硬化（0.0517 +/- 0.0365; 54.65 +/- 53.26; 0.838 +/- 0.929）与对照组的测量值存在显著差异（0.0123 ± 0.0081; 10.95 ± 7.07; 0.2438 ± 0.1568），P < 0.0001-0.002）。在克罗恩病中，乳果糖/甘露醇比值在临界水平0.022时的特异性、灵敏度和AUC分别为100%、89.5%和0.987。在肝硬化中，在0.018的临界水平下，测试特征分别为88.5%、84.2%和0.910。结论乳果糖/甘露醇比值对小肠通透性的诊断价值最高。
The purpose of this study was to investigate and compare the specificity, sensitivity, and area under curve (AUC) of the lactulose/mannitol ratio, lactulose/creatinine ratio, and lactulose recovery and their diagnostic value for intestinal permeability assessment within the absorption lactulose/mannitol (L/M) test. Results The value of the lactulose/mannitol ratio, lactulose/creatinine ratio, and the percentage of lactulose recovery in Crohn's disease (0.0763 +/- 0.0369; 99.62 +/- 67.87; 1.0478 +/- 0.6148) and in liver cirrhosis (0.0517 +/- 0.0365; 54.65 +/- 53.26; 0.838 +/- 0.929) were significantly different from the values measured in the control group (0.0123 +/- 0.0081; 10.95 +/- 7.07; 0.2438 +/- 0.1568), P < 0.0001-0.002). In Crohn's disease, specificity, sensitivity, and AUC were 100%, 89.5%, and 0.987, respectively, of the lactulose/mannitol ratio at a cut-off level of 0.022. In liver cirrhosis, the test characteristics were 88.5%, 84.2%, and 0.910 at a cut-off level of 0.018. Conclusion The lactulose/mannitol ratio was evaluated to have the highest diagnostic value to assess intestinal permeability.