Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: A randomised, placebo controlled trial
Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: A randomised, placebo controlled trial
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DOI：
10.1136/gut.40.4.485
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发表时间：
1997-04-01
期刊：
影响因子：
24.5
通讯作者：
Rademaker, AW
中科院分区：
文献类型：
--
作者：
Breuer, RI;Soergel, KH;Rademaker, AW
短链脂肪酸（SCFA）缺乏与动物和人类结肠炎有关，溃疡性结肠炎患者这些化合物的粘膜代谢降低。目的：评价局部SCFA治疗溃疡性结肠炎的疗效。患者和方法：103例远端溃疡性结肠炎患者进入一项为期6周、双盲、安慰剂对照的直肠SCFA试验，每天两次；在一项开放标签扩展试验中，未服用安慰剂的患者接受SCFA治疗。结果：在完成试验的91例患者中，SCFA治疗组的患者比安慰剂治疗组有更多的患者得到改善（33% v 20%, p=0.14， NS）。那些服用SCFA的患者在临床和组织学活动评分的每个组成部分都有较大的下降，但在统计学上不显著。当前结肠炎发作时间相对较短的患者(
Background-Short chain fatty acid (SCFA) deficiency is associated with colitis in animals and humans, and the mucosal metabolism of these compounds is decreased in ulcerative colitis.Aims-To assess the efficacy of topical SCFA treatment in ulcerative colitis.Patients and Methods-103 patients with distal ulcerative colitis were entered into a six week, double-blind, placebo controlled trial of rectal SCFA twice daily; patients who were unchanged on placebo were offered SCFA in an open-label extension trial.Results-Of the 91 patients completing the trial, more patients in the SCFA treated than in the placebo treated group improved (33% v 20%, p=0.14, NS). Those on SCFA also had larger, but statistically non-significant, reductions in every component of their clinical and histological activity scores. In patients with a relatively short current episode of colitis (