Specific effect of selenium deficiency on rat sperm.
Specific effect of selenium deficiency on rat sperm.
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DOI：
10.1095/biolreprod20.4.793
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发表时间：
1979-05
影响因子：
3.6
通讯作者：
A. S. Wu;J. Oldfield;L. Shull;P. Cheeke
中科院分区：
文献类型：
--
作者：
A. S. Wu;J. Oldfield;L. Shull;P. Cheeke
描述了缺硒雄性大鼠的生殖障碍。在4、11和12个月的缺硒（<0.02 ppm）饮食后，观察到身体和睾丸重量的减少，虽然幅度不大，但有时是显著的。4个月间隔后，精子形态和活力恢复正常，但11个月和12个月间隔组中50%的动物产生的精子活力受损，并出现典型的中段断裂。由于形态异常似乎与身体和睾丸重量的影响无关，硒对精子的影响被认为是相当特定的。讨论了硒依赖性酶谷胱甘肽过氧化物酶（GSH-Px）在维持精子膜完整性中的可能参与。
Reproductive disorders in Se-deficient male rats from Se-adequate dams are described. After 4, 11 and 12 months on the Se-deficient (<0.02 ppm) diet, small, but sometimes significant, reductions in body and testicular weights were observed. Sperm morphology and motility appeared to be normal after the 4 month interval, but 50% of the animals in the 11 and 12 month interval groups produced sperm with impaired motility and a characteristic midpiece breakage. Because the morphologic anomaly does not appear to be correlated with effects on body and testicular weights, the effect of selenium on sperm is thought to be rather specific. The possible involvement of the Se-dependent enzyme glutathione peroxidase (GSH-Px) in maintaining the integrity of the sperm membrane is discussed.