The long noncoding RNA‐ROR promotes the resistance of radiotherapy for human colorectal cancer cells by targeting the p53/miR‐145 pathway
The long noncoding RNA‐ROR promotes the resistance of radiotherapy for human colorectal cancer cells by targeting the p53/miR‐145 pathway
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DOI：
10.1111/jgh.13606
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发表时间：
2017-04
影响因子：
4.1
通讯作者：
Pengxiang Yang;Yue Yang;Weiwei An;Jianyu Xu;Gan Zhang;Jing Jie;Qingyuan Zhang
中科院分区：
文献类型：
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作者：
Pengxiang Yang;Yue Yang;Weiwei An;Jianyu Xu;Gan Zhang;Jing Jie;Qingyuan Zhang
Long intergenic noncoding RNAs (lincRNAs) have critical roles in elevating efficacy of anticancer therapy and tumor progression. Recent studies show that Regulator of Reprogramming (ROR) is aberrantly expressed in several types of cancer, including colorectal cancer (CRC). Radiotherapy is considered as a standard preoperative treatment. However, a considerable number of CRCs are resistant to radiotherapy. In this study, we evaluated the role of lincRNA‐ROR in radiotherapy for CRC and detected the underlying molecular mechanism.
