Reinventing the wheel of cyclic AMP - Novel mechanisms of cAMP signaling
Reinventing the wheel of cyclic AMP - Novel mechanisms of cAMP signaling
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DOI：
10.1111/j.1749-6632.2002.tb04326.x
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Iacono, L
中科院分区：
文献类型：
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作者：
Chin, KV;Yang, WL;Iacono, L
CAMP信号转导的机制已经被深入研究了40多年。从激素配体与质膜外表面受体的结合到效应物的胞质活化，随后的CAMP信号级联和核基因调控功能，再加上对CAMP依赖性蛋白激酶（PKA）的结构解析和同源重组基因靶向对PKA各组分的体内功能表征。我们对camp介导的信号转导的理解已经达到了顶峰。尽管有这些知识宝库，但最近的一些发现表明，迄今为止，CAMP作用的新颖和替代机制可能会增加CAMP和PKA在细胞生长和转录调节中的信号带宽。本文试图回顾一些新的和非常规的CAMP和PKA信号转导机制，并进一步激发人们对CAMP信号转导途径的研究和验证的热情。
Mechanisms of CAMP signal transduction have been thoroughly investigated for more than 40 years. From the binding of hormonal ligands to their receptors on the outer surface of the plasma membrane to the cytoplasmic activation of effectors, the ensuing CAMP signaling cascades and the nuclear gene regulatory functions, coupled with the structural elucidation of the cAMP-dependent protein kinase (PKA) and in vivo functional characterizations of each of the components of PKA by homologous recombination gene targeting, our understanding of cAMP-mediated signal transduction has reached its pinnacle. Despite this trove of knowledge, some recent findings have emerged that suggest hitherto novel and alternative mechanisms of CAMP action that could increase the signaling bandwidth of CAMP and PKA in cell growth and transcriptional regulation. This article attempts to review some of these novel and unconventional mechanisms of CAMP and PKA signaling, and to generate further enthusiasm in investigating and validating these new frontiers of the CAMP signal transduction pathway.