Brown adipose tissue: a promising target to combat obesity.
Brown adipose tissue: a promising target to combat obesity.
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DOI：
10.1358/dnp.2010.23.7.1487083
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发表时间：
2010-09
影响因子：
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通讯作者：
C. Vernochet;Meghan E. McDonald;S. Farmer
中科院分区：
文献类型：
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作者：
C. Vernochet;Meghan E. McDonald;S. Farmer
肥胖现在已经达到流行病的程度，导致一系列被称为代谢综合征的疾病，包括胰岛素抵抗、2型糖尿病和心血管疾病。脂肪组织的扩张是这些合并症的直接原因，因为脂肪细胞内甘油三酯过度积累，导致正常脂肪功能的破坏。有两种主要类型的脂肪组织，白色和棕色。前者在大液滴中以甘油三酯的形式储存能量，而后者则分解脂质以产生热量。因此，对抗肥胖相关疾病的策略包括通过靶向最近鉴定的棕色脂肪细胞发育和功能的调节剂（包括其主调节剂PRDM16）来增强棕色脂肪组织活性。
Obesity has now reached pandemic proportions leading to a collection of morbidities referred to as metabolic syndrome including insulin resistance, type 2 diabetes and cardiovascular disease. The expansion of adipose tissue is a direct cause of these comorbidities due to excessive accumulation of triglycerides within adipocytes, causing disruption of normal adipose function. There are two major types of adipose tissue, white and brown. The former stores energy as triglycerides within large droplets, whereas the latter catabolizes lipids to produce heat. A strategy to combat obesity-associated disorders, therefore, includes enhancement of brown adipose tissue activity by targeting the recently identified regulators of brown adipocyte development and function, including its master regulator, PRDM16.