In vivo confocal and multiphoton microendoscopy

In vivo confocal and multiphoton microendoscopy
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DOI:
10.1117/1.2839043
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发表时间:
2008-01-01
影响因子:
3.5
通讯作者:
Yun, Seok H.
Yun, Seok H.
中科院分区:
医学3区
文献类型:
--
作者:
Kim, Pilhan;Puoris'haag, Mehron;Yun, Seok H.

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随着时间的推移,在小动物模型的内脏器官中进行高分辨率荧光成像的能力可以在生物医学研究中产生重大影响。为此,我们研制了一种实时共焦多光子内窥镜成像系统。使用1毫米直径的内窥镜梯度折射率透镜的基础上,我们证明了视频率的多模态成像与细胞分辨率活小鼠。(C)2008年,由光学仪器工程师协会(Society of Photo-Optical Instrumentation Engineers)主办。
The ability to conduct high-resolution fluorescence imaging in internal organs of small animal models in situ and over time can make a significant impact in biomedical research. Toward this goal, we developed a real-time confocal and multiphoton endoscopic imaging system. Using 1-mm-diameter endoscopes based on gradient index lenses, we demonstrate video-rate multicolor multimodal imaging with cellular resolution in live mice. (C) 2008 Society of Photo-Optical Instrumentation Engineers.