Depressive symptoms among survivors of Ebola virus disease in Conakry (Guinea): preliminary results of the PostEboGui cohort.
Depressive symptoms among survivors of Ebola virus disease in Conakry (Guinea): preliminary results of the PostEboGui cohort.
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DOI：
10.1186/s12888-017-1280-8
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发表时间：
2017-04-04
期刊：
影响因子：
4.4
通讯作者：
PostEboGui Study Group
中科院分区：
文献类型：
--
作者：
Keita MM;Taverne B;Sy Savané S;March L;Doukoure M;Sow MS;Touré A;Etard JF;Barry M;Delaporte E;PostEboGui Study Group
截至2016年5月11日，西非爆发的埃博拉疫情感染了28,616人，造成11,310人死亡，涉及6个国家。疫情还导致了历史上最多的埃博拉病毒幸存者--超过17,000人。2016年6月1日，几内亚宣布无埃博拉疫情。疫情报告记录了3814例，导致2544人死亡，1270人幸存。EVD幸存者面临各种神经心理和心理情感变化，这些变化尚未完全确定。这项研究旨在记录几内亚成年幸存者的抑郁症状。使用法国版流行病学研究中心抑郁量表(CES-D)对所有成年幸存者(≥20年)进行抑郁症状调查，这些幸存者参与了后埃博圭研究并在科纳克里接受护理。这项研究与科纳克里东卡国家医院的精神病学家的临床咨询相结合，以确保在需要时提供适当的护理。总体而言，在科纳克里接受护理的256名成年参与者参与了这项研究：55%是女性，中位年龄31岁[IQR：26-40]。埃博拉治疗中心(ETC)出院以来的中位时间为8.1个月[IQR：4.1-11.7]。15%的人得分高于临界值，表明心理痛苦(男性为15%，女性为14%)。33人(16名女性和17名男性)去看精神科医生，结果诊断出3例创伤后应激障碍(PTSD)，3例轻度抑郁症，13例中度抑郁症，11例重度抑郁症，包括1例动觉幻觉和1例视觉幻觉，1例有自杀意念，3例自杀未遂。ETC出院后1~19个月诊断为重度抑郁症。各种确定的抑郁症形式对传统药物疗法和认知行为疗法反应良好。有必要对EVD幸存者进行长期随访，以了解这些病理的演变。在当前的疫情后背景下，这些病例突出表明有必要在全国范围内加强精神卫生诊断系统和治疗。本文的在线版本(doi：10.1186/s12888-017-1280-8)包含补充材料，授权用户可以使用。
The 2013–2016 West African Ebola outbreak infected 28,616 people and caused 11,310 deaths by 11 May 2016, across six countries. The outbreak has also resulted in the largest number of EVD survivors in history—over 17,000. Guinea was declared Ebola-free on 1 June 2016. Reports from the outbreak documented 3814 cases resulting in 2544 deaths and 1270 survivors. EVD survivors face various neuropsychological and psycho-affective alterations that have not been fully identified yet. This study aims to document the depressive symptoms among adult survivors in Guinea. Depressive symptoms were investigated using the French version of the Center for Epidemiologic Studies-Depression Scale (CES-D) administered to all adult survivors (≥ 20 years) participating in the PostEboGui study and receiving care in Conakry. The study was combined with a clinical consultation by a psychiatrist at the Donka National Hospital in Conakry that ensured adapted care was provided when needed. Overall, 256 adult participants receiving care in Conakry participated in this study: 55% were women, median age 31 years [IQR: 26–40]. The median time since the Ebola Treatment Center (ETC) discharge was 8.1 months [IQR: 4.1–11.7]. 15% had a score above the threshold values indicating psychological suffering (15% for men and 14% for women). 33 people (16 women and 17 men) met with the psychiatrist, which resulted in the diagnosis of 3 cases of post-traumatic stress disorder (PTSD), 3 cases of mild depression, 13 cases of moderate depression, and 11 cases of severe depression, including 1 with kinesthetic hallucinations and another with visual hallucinations, and 1 with suicidal ideation and 3 with attempted suicide. Severe depression was diagnosed between 1 and 19 months after ETC discharge. The various identified forms of depression responded favorably to conventional drug therapies and cognitive behavioral therapy. Long-term follow-up for EVD survivors will be necessary to understand the evolution of these pathologies. In the current post-epidemic context, these cases underscore the need to strengthen mental health diagnostic systems and treatment on a national scale. The online version of this article (doi:10.1186/s12888-017-1280-8) contains supplementary material, which is available to authorized users.