Naringenin and Hesperetin, Two Flavonoids Derived from Citrus aurantium Up-regulate Transcription of Adiponectin
Naringenin and Hesperetin, Two Flavonoids Derived from Citrus aurantium Up-regulate Transcription of Adiponectin
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DOI：
10.1002/ptr.2504
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发表时间：
2008-10-01
影响因子：
7.2
通讯作者：
Cheng, Yi-Yu
中科院分区：
文献类型：
--
作者：
Liu, Li;Shan, Song;Cheng, Yi-Yu
干燥的，未成熟的柑橘果实，几个世纪以来，中国传统医学一直用“治桥”来治疗心血管疾病。该草药中存在大量的柚素和橙皮素及其苷（约10%至15%）。本研究的目的是测试柚素和橙皮素是否影响脂联素的表达，脂联素在葡萄糖和脂质代谢中发挥重要作用，具有抗动脉粥样硬化和抗炎作用。用柚皮素和橙皮素处理增强分化的3 T3-L1细胞中脂联素的转录。柚皮素和橙皮素诱导过氧化物酶体增殖物激活受体（PPAR）γ-控制的荧光素酶表达的剂量依赖性方式（20160 μ M），而只有柚皮素具有显着的活性，激活过氧化物酶体增殖物激活受体α。结果提示，两种黄酮类化合物可能通过激活脂肪细胞的过氧化物酶体增殖物激活受体，上调脂联素的表达而发挥抗动脉粥样硬化的作用。我们的研究结果提供了新的见解的分子解释的治疗作用，栀翘。版权所有（C）2008约翰威利父子有限公司
The dried, immature fruit of Citrus aurantium L., 'Zhiqiao' in Chinese, has been used to treat cardiovascular diseases in traditional Chinese medicine for centuries. Naringenin and hesperetin and their glycosides present in considerable amounts (about 10 similar to 15%) in the herb. The aim of this study is to test whether naringenin and hesperetin influence adiponectin expression, which plays an important role in glucose and lipid metabolism with antiatherogenic and anti-inflammatory properties. Treatment with naringenin and hesperetin enhanced adiponectin transcription in differentiated 3T3-L1 cells. Both naringenin and hesperetin induced peroxisome proliferator-activated receptor (PPAR)gamma-controlled luciferase expression in a dose-dependent manner (20160 mu M), whereas only naringenin possessed significant activity to activate PPAR alpha. These results suggested the two flavonoids might exert antiatherogenic effects partly through activating PPAR and up-regulating adiponectin expression in adipocytes. Our findings give new insight for the molecular explanations for the therapeutic effects of Zhiqiao. Copyright (C) 2008 John Wiley & Sons, Ltd.