IDENTIFICATION OF AN ALTERNATIVE CTLA-4 LIGAND COSTIMULATORY FOR T-CELL ACTIVATION
IDENTIFICATION OF AN ALTERNATIVE CTLA-4 LIGAND COSTIMULATORY FOR T-CELL ACTIVATION
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DOI：
10.1126/science.7694361
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发表时间：
1993-11-05
期刊：
影响因子：
56.9
通讯作者：
HODES, RJ
中科院分区：
文献类型：
--
作者：
HATHCOCK, KS;LASZLO, G;HODES, RJ
T细胞增殖的刺激通常需要两个信号：第一个信号由T细胞受体与抗原结合提供，第二个信号或共刺激信号由不同的受体 - 配体相互作用提供。在小鼠和人类中，CD28 - B7相互作用已被确定为共刺激信号的一个来源。我们已经鉴定出一种细胞表面分子（GL1），它不同于B7，且在活化的B细胞上大量表达。在活化的B细胞上，GL1而非B7是T细胞活化分子CTLA - 4的主要配体。GL1在体外和体内为T细胞依赖性反应提供关键信号。
Stimulation of T cell proliferation generally requires two signals: The first signal is provided by the T cell receptor binding to antigen, and the second signal or costimulus is provided by a different receptor-ligand interaction. In mouse and human, the CD28-B7 interaction has been identified as a source of costimulatory signals. We have identified a cell surface molecule (GL1) that is distinct from B7 and abundantly expressed on activated B cells. On activated B cells GL1, rather than B7, is the predominant ligand for the T cell-activation molecule CTLA-4. GL1 provides a critical signal for T cell-dependent responses in vitro and in vivo.