Adverse effect of combination of chronic psychosocial stress and high fat diet on hippocampus-dependent memory in rats
Adverse effect of combination of chronic psychosocial stress and high fat diet on hippocampus-dependent memory in rats
复制标题
DOI：
10.1016/j.bbr.2009.05.025
复制
发表时间：
2009-12-01
影响因子：
2.7
通讯作者：
Alkadhi, K. A.
中科院分区：
文献类型：
--
作者：
Alzoubi, K. H.;Abdul-Razzak, K. K.;Alkadhi, K. A.
使用径向臂水迷宫（RAWM）研究了高脂肪饮食（HFD）和慢性压力对大鼠海马依赖性空间学习和记忆的综合影响。对年轻成年雄性 Wister 大鼠同时给予慢性社会心理压力和/或 HFD 3 个月。在 RAWM 中，老鼠接受了 12 项学习试验以及短期和长期记忆测试。每天应用此程序，直到动物在第 12 次学习试验和记忆测试中达到标准天数 (DTC)。 DTC 是动物连续两天出现零错误所需的天数。根据每次试验或测试的错误数以及 DTC 对各组进行比较。慢性应激、HFD 和慢性应激/HFD 动物组表现出学习障碍，在第 4 天的第 6 至 9 次试验中，与未治疗的对照组相比，犯下的错误显着增加 (P < 0.05)。在记忆测试中，与对照组相比，慢性应激、HFD 和慢性应激/HFD 组的表现明显受损。此外，压力/HFD 组是唯一在第 5 个训练日的记忆测试中表现出明显受损的组，表明该组的记忆损伤更为严重。此外，上述各组的DTC值表明，单独的慢性压力或HFD会导致轻微的空间记忆损害，但慢性压力和HFD的结合会导致更严重和持久的记忆损害。数据表明，压力和 HFD 的结合比单独的慢性压力或 HFD 对海马认知功能产生更有害的影响。 (C) 2009 Elsevier B.V. 保留所有权利。
The combined effects of high fat diet (HFD) and chronic stress on the hippocampus-de pendent spatial learning and memory were studied in rats using the radial arm water maze (RAWM). Chronic psychosocial stress and/or HFD were simultaneously administered for 3 months to young adult male Wister rats. In the RAWM, rats were subjected to 12 learning trials as well as short-term and long-term memory tests. This procedure was applied on a daily basis until the animal reaches days to criterion (DTC) in the 12th learning trial and in memory tests. DTC is the number of days that the animal takes to make zero error in two consecutive days. Groups were compared based on the number of errors per trial or test as well as on the DTC. Chronic stress, HFD and chronic stress/HFD animal groups showed impaired learning as indicated by committing significantly (P < 0.05) more errors than untreated control group in trials 6 through 9 of day 4. In memory tests, chronic stress, HFD and chronic stress/HFD groups showed significantly impaired performance compared to control group. Additionally, the stress/HFD was the only group that showed significantly impaired performance in memory tests on the 5th training day, suggesting more severe memory impairment in that group. Furthermore, DTC value for above groups indicated that chronic stress or HFD, alone, resulted in a mild impairment of spatial memory, but the combination of chronic stress and HFD resulted in a more severe and long-lasting memory impairment. The data indicated that the combination of stress and HFD produced more deleterious effects on hippocampal cognitive function than either chronic stress or HFD alone. (C) 2009 Elsevier B.V. All rights reserved.