Association between periodontal disease and pericardial adipose tissue in patients with cardiovascular disease
Association between periodontal disease and pericardial adipose tissue in patients with cardiovascular disease
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DOI：
10.1016/j.ahjo.2023.100298
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发表时间：
2023-05-11
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影响因子：
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通讯作者：
Sasano，Tetsuo
中科院分区：
文献类型：
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作者：
Kanno，Yoshinori;Yonetsu，Taishi;Sasano，Tetsuo
背景牙周病（PD）与心血管疾病（CVD）的风险增加有关。心包脂肪组织（PAT）是进行性CVD的标志物。本研究旨在评估PD和PAT之间的关联在患者CVD.MethodsWe回顾性调查了135例接受计算机断层扫描冠状动脉造影（CTCA）和牙周检查的CVD患者。牙周病评估使用社区牙周指数（CPI）的基础上，探测袋深度周围的牙齿。CPI ≥3的患者被归类为PD。使用CTCA图像，采用定量半自动程序测量PAT体积。根据PAT体积将患者分为三分位数。基线特征和PD的结果进行了比较之间的tertiels. Results八十六例患者被诊断为PD（63.7%）。平均PAT体积为181.4 ml，患者分为小型PAT（PAT <148.9 ml）、中型PAT（148.9 ml ≤ PAT ≤204.6 ml）和大型PAT（PAT >204.6 ml）。大PAT患者的PD患病率（38/46，82.6%）显著高于小PAT患者（18/45，40.0%）和中等PAT患者（30/44，68.2%）。多因素Logistic回归分析显示，体重、高血压病史和PD是大PAT的独立预测因素（比值比[OR]：1.12，P < 0.001，OR：3.97，P = 0.017，OR：结论肺动脉瓣体积与PD的发生及严重程度密切相关，与进行性心血管疾病有关需要进一步的前瞻性研究来评估PD对CVD发病和结局的影响。
BackgroundPeriodontal disease (PD) is associated with an increased risk of cardiovascular disease (CVD). Pericardial adipose tissue (PAT) is known as a marker of progressive CVD. This study sought to assess the association between PD and PAT in patients with CVD.MethodsWe retrospectively investigated 135 patients admitted for CVD who underwent computed tomography coronary angiography (CTCA) and periodontal examinations. Periodontal assessment using the community periodontal index (CPI) was based on the probing pocket depth around teeth. Patients with CPI ≥3 were categorized as having PD. PAT volume was measured with a quantitative semi-automated procedure using CTCA images. Patients were divided into tertiles according to PAT volume. Baseline characteristics and PD findings were compared among the tertiles.ResultsEighty-six patients were diagnosed with PD (63.7 %). Mean PAT volume was 181.4 ml, and patients were categorized as small-PAT (PAT <148.9 ml), intermediate-PAT (148.9 ml ≤ PAT ≤204.6 ml), and large-PAT (PAT >204.6 ml). The prevalence of PD was significantly higher in large-PAT (38/46, 82.6 %) than in small-PAT (18/45, 40.0 %) and intermediate-PAT (30/44, 68.2 %) patients. Multivariate logistic regression analysis showed that body weight, history of hypertension, and the presence of PD were independent predictors for large-PAT (odds ratio [OR]: 1.12,P< 0.001, OR: 3.97,P= 0.017, and OR: 4.18,P= 0.0078, respectively).ConclusionThe presence and severity of PD were significantly correlated with PAT volume, which has been associated with progressive CVD. Further prospective studies are warranted to assess the impact of PD on the onset and outcomes of CVD.