Second primary respiratory tract malignancies in glottic carcinoma
Second primary respiratory tract malignancies in glottic carcinoma
复制标题
声门癌中的第二原发呼吸道恶性肿瘤
作者：
D. Wagenfeld;A. Harwood;D. Bryce;A. V. van Nostrand;G. Deboer
在 740 例声门癌病例中，有 48 例出现第二呼吸道肿瘤。在从安大略省普通人群中抽取的相同年龄和性别分布的样本中，预计只会出现 14 例。 25 名肺部第二个肿瘤患者中，23 人死亡。在这 23 人中，17 人的 T1 期声门癌已被治愈。描述了一种计算声门癌幸存者患第二呼吸道肿瘤风险的精算方法。在幸存者中，12% 的人在初次诊断为声门癌后十年内会出现第二次呼吸道肿瘤。 T1 期声门癌患者中，7% 将在十年内死于第二呼吸道肿瘤。这一比率略高于该阶段分组中死于喉癌的人。放疗后晚期复发和/或喉部第二原发肿瘤很少见。讨论了降低第二呼吸道肿瘤死亡风险的方法。
Of 740 cases of glottic cancer, a second respiratory tract tumor developed in 48. Only 14 cases would have been expected in a sample of the same age and sex distribution drawn from the general population of Ontario. Of 25 patients with second tumors in the lung, 23 are dead. Of these 23, 17 had been cured of Stage T1 glottic cancer. An actuarial method for calculating the risk of developing a second respiratory tract tumor amongst the survivors of glottic cancer is described. Of the survivors, 12% will have a second respiratory tract tumor within ten years following initial diagnosis of glottic cancer. Of patients with Stage T1 glottic cancer, 7% will die of a second respiratory tract tumor within ten years. This rate is slightly more than that for those who die of laryngeal cancer in this stage grouping. Late recurrences and/or second primary tumors in the larynx following radiotherapy are rare. Methods for reducing the risk of death from a second respiratory tract tumor are discussed.