Processing of vitamin A and E in the human gastrointestinal tract
Processing of vitamin A and E in the human gastrointestinal tract
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DOI：
10.1152/ajpgi.2001.280.1.g95
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发表时间：
2001-01-01
影响因子：
4.5
通讯作者：
Azais-Braesco, V
中科院分区：
文献类型：
--
作者：
Borel, P;Pasquier, B;Azais-Braesco, V
我们的目的是提供维生素 A 和 E 在人体胃肠道中加工的基本数据，并评估乳化脂肪球的大小是否影响这些维生素的生物利用度。八名健康男性在胃内接受了两种脂肪球中值直径不同的脂质配方（0.7 vs. 10.1 mum）。配方提供 28 毫克维生素 A（视黄醇棕榈酸酯）和 440 毫克维生素 E（全 RAC α-生育酚）。在餐后期间测量胃和十二指肠抽吸物以及乳糜微粒中的维生素。脂质和维生素A和E的胃排空率相似。游离视黄醇/总维生素A的比例在胃中没有显着改变，而在十二指肠中则显着增加。十二指肠内容物中摄入的脂质和维生素的比例非常相似。两种乳液之间的脂质和维生素的乳糜微粒反应没有显着差异。我们的主要结论如下：1）维生素A和E在人胃中没有显着的代谢，2）十二指肠腔中存在的酶显着参与视黄酯的水解，3）乳化脂肪球的大小对维生素A和E的总体吸收没有重大影响。
We aimed to provide basic data on the processing of vitamin A and E in the human gastrointestinal tract and to assess whether the size of emulsion fat globules affects the bioavailability of these vitamins. Eight healthy men received intragastrically two lipid formulas differing in their fat-globule median diameter (0.7 vs. 10.1 mum). Formulas provided 28 mg vitamin A as retinyl palmitate and 440 mg vitamin E as all-rac alpha -tocopherol. Vitamins were measured in gastric and duodenal aspirates, as well as in chylomicrons, during the postprandial period. The gastric emptying rate of lipids and vitamin A and E was similar. The free retinol/total vitamin A ratio was not significantly modified in the stomach, whereas it was dramatically increased in the duodenum. The proportion of ingested lipid and vitamins was very similar in the duodenal content. The chylomicron response of lipids and vitamins was not significantly different between the two emulsions. Our main conclusions are as follows: 1) there is no significant metabolism of vitamin A and E in the human stomach, 2) the enzyme(s) present in the duodenal lumen is significantly involved in the hydrolysis of retinyl esters, and 3) the size of emulsion fat globules has no major effect on the overall absorption of vitamin A and E.