The global burden of sepsis: barriers and potential solutions.

The global burden of sepsis: barriers and potential solutions.
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DOI:
10.1186/s13054-018-2157-z
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发表时间:
2018-09-23
期刊:
Critical care (London, England)
影响因子:
--
通讯作者:
West TE
West TE
中科院分区:
其他
文献类型:
--
作者:
Rudd KE;Kissoon N;Limmathurotsakul D;Bory S;Mutahunga B;Seymour CW;Angus DC;West TE

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脓毒症是全球疾病负担的主要贡献者。据估计,大多数败血症病例和死亡发生在低收入和中等收入国家。减少脓毒症全球负担的障碍包括难以量化可归因的发病率和死亡率、认识不足、贫困和健康不平等,以及资源不足和低弹性的公共卫生和急性医疗保健提供系统。在高和低资源环境中,处于危险中的人群、感染病原体和管理脓毒症的临床能力的重要差异需要针对这一重大问题采取特定背景的方法。我们回顾这些挑战,并提出克服这些挑战的战略。这些战略包括加强卫生系统,准确识别和量化脓毒症病例,开展包容性研究,建立数据驱动和特定背景的管理指南,促进创造性的临床干预措施和宣传。
Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy.
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