Widespread dissemination in The Netherlands of the epidemic Berlin methicillin-resistant Staphylococcus aureus clone with low-level resistance to oxacillin
Widespread dissemination in The Netherlands of the epidemic Berlin methicillin-resistant Staphylococcus aureus clone with low-level resistance to oxacillin
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DOI：
10.1128/jcm.42.7.3077-3082.2004
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发表时间：
2004-07-01
影响因子：
9.4
通讯作者：
de Neeling, AJ
中科院分区：
文献类型：
--
作者：
Wannet, WJB;Spalburg, E;de Neeling, AJ
耐甲氧西林金黄色葡萄球菌（MRSA）是一种重要的人类病原体，由于流行菌株的出现和传播，特别是在医院环境中，MRSA代表了日益增长的公共卫生负担。2000年出现了一种流行性MRSA克隆，对苯唑西林具有低水平的耐药性，并在荷兰流行。多位点序列分型将该菌株鉴定为序列型45，其先前被指定为柏林流行性MRSA克隆。在2年内，该菌株已成为荷兰主要的MRSA克隆。
Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen and represents a growing public health burden due to the emergence and spread of epidemic strains, particularly within the hospital environment. An epidemic MRSA clone, with characteristic low-level resistance to oxacillin, emerged in the year 2000 and became endemic in the Netherlands. Multilocus sequence typing characterized the strain as sequence type 45, which was previously designated the Berlin epidemic MRSA clone. In 2 years, this strain has become the predominant MRSA clone in the Netherlands.