The evolution of a genetic locus encoding small serine proteinase inhibitors
The evolution of a genetic locus encoding small serine proteinase inhibitors
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DOI：
10.1016/j.bbrc.2005.05.125
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发表时间：
2005-07-29
影响因子：
3.1
通讯作者：
Lundwall, Å
中科院分区：
文献类型：
--
作者：
Clauss, A;Lilja, H;Lundwall, Å
我们之前在人类20号染色体上发现了一个包含14个wfdc型蛋白酶抑制剂基因的位点，这些基因在先天免疫中具有潜在的作用。在一项扩展的研究中，同源位点在小鼠的2号染色体、大鼠的3号染色体和狗的24号染色体上描述。与人类一样，小鼠和犬的基因座被分成两个相距0.2 Mb的亚位点。大多数基因在所有物种中都是保守的，但也存在物种特异性基因的获得和损失，例如，在大鼠中多次复制产生了四个SLPI基因，最令人惊讶的是，没有小鼠elafin基因。由于啮齿类动物功能基因的发现，鉴定出两个人类假基因。不同WFDC结构域的保守性差异很大，据推测，这反映了WFDC抑制剂在自然免疫中的双重作用，既针对微生物，也针对促炎细胞。(c) 2005爱思唯尔公司版权所有。
We previously identified a locus on human chromosome 20 that encompasses 14 genes of postulated WFDC-type proteinase inhibitors with a potential role in innate immunity. In an extended study, homologous loci are here described on mouse chromosome 2, rat chromosome 3, and dog chromosome 24. As in humans, the murine and canine loci are divided into two sub-loci separated by 0.2 Mb. The majority of genes are conserved in all species, but there are also species-specific gains and losses of genes, e.g., several duplications have yielded four SLPI genes in the rat and, most surprisingly, there is no murine elafin gene. Two human pseudogenes were identified due to the discovery of functional rodent genes. The conservation of different WFDC domains varies considerably, and it is hypothesized that this reflects a dual role of WFDC inhibitors in natural immunity, which is directed both against microbes and proinflammatory cells. (c) 2005 Elsevier Inc. All rights reserved.