New bioactive taxoids from cell cultures of Taxus baccata.
New bioactive taxoids from cell cultures of Taxus baccata.
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DOI：
10.1021/np50103a016
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发表时间：
1994
影响因子：
5.1
通讯作者：
W. Ma;G. Park;G. A. Gomez;M. Nieder;T. Adams;J. Aynsley;O. Sahai;R. Smith;R. W. Stahlhut;P. Hylands
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文献类型：
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作者：
W. Ma;G. Park;G. A. Gomez;M. Nieder;T. Adams;J. Aynsley;O. Sahai;R. Smith;R. W. Stahlhut;P. Hylands
从红豆杉细胞培养物中分离得到4个新的紫杉类化合物。通过波谱分析确定了它们的结构。其中两个是与先前分离的紫杉醇C的7-O-木糖苷[1]和10-脱乙酰基紫杉醇C[2]相对应的苷元。第三个[3]有一个N-甲基化的侧链，而第四个，命名为紫杉烷[4]，在侧链上含有一个正丙基。所有四个化合物都积极地促进微管蛋白的组装。紫杉醇C[1]在NCI人细胞系筛选中表现出较强的选择性细胞毒作用。
Four new taxoids were isolated from cell cultures of Taxus baccata. Their structures were elucidated by spectroscopic analyses. Two were the aglycones corresponding to previously isolated 7-O-xylosides of taxol C [1] and 10-deacetyltaxol C [2]. The third [3] had an N-methylated side-chain, while the fourth, named taxcultine [4], contained an n-propyl group on the side-chain. All four compounds actively promoted tubulin assembly. Taxol C [1] showed potent and selective cytotoxicity in the NCI human cell line screen.