Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation.
Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation.
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DOI：
10.1111/jcmm.16538
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发表时间：
2021-06
影响因子：
5.3
通讯作者：
Guo L
中科院分区：
文献类型：
--
作者：
Li B;Chen K;Qian N;Huang P;Hu F;Ding T;Xu X;Zhou Q;Chen B;Deng L;Ye T;Guo L
骨关节炎（OA）是一种最常见的慢性关节疾病，随着人类寿命的延长。该疾病的主要特征是关节软骨丧失，软骨下骨硬化和滑膜炎症。骨性关节炎的治疗以物理措施、药物治疗和手术治疗为主，由于骨性关节炎关节治疗靶点单一，药物治疗主要局限于止痛剂、糖皮质激素、透明质酸等药物及一些替代疗法。黄芩素是一种从黄芩中提取的中药，被广泛用于抗炎治疗。已有研究表明黄芩苷可通过作用于关节软骨细胞，有效缓解软骨退行性变。然而，考虑到关节的完整性，黄芩素介导的OA保护机制尚不完全清楚。在这项研究中，我们发现关节内注射黄芩素改善软骨下骨重塑。进一步研究表明黄芩素可通过抑制成骨前细胞增殖和促进成骨前细胞凋亡来减少成骨细胞的分化数量。此外，黄芩素损害内皮细胞的血管生成，抑制滑膜细胞的增殖。综上所述，这些结果暗示黄芩素可能是一种通过调节多个靶点来治疗OA的有效药物。
Osteoarthritis (OA) is one of the most frequent chronic joint diseases with the increasing life expectancy. The main characteristics of the disease are loss of articular cartilage, subchondral bone sclerosis and synovium inflammation. Physical measures, drug therapy and surgery are the mainstay of treatments for OA, whereas drug therapies are mainly limited to analgesics, glucocorticoids, hyaluronic acids and some alternative therapies because of single therapeutic target of OA joints. Baicalein, a traditional Chinese medicine extracted from Scutellaria baicalensis Georgi, has been widely used in anti‐inflammatory therapies. Previous studies revealed that baicalein could alleviate cartilage degeneration effectively by acting on articular chondrocytes. However, the mechanisms involved in baicalein‐mediated protection of the OA are not completely understood in consideration of integrality of arthrosis. In this study, we found that intra‐articular injection of baicalein ameliorated subchondral bone remodelling. Further studies showed that baicalein could decrease the number of differentiated osteoblasts by inhibiting pre‐osteoblasts proliferation and promoting pre‐osteoblasts apoptosis. In addition, baicalein impaired angiogenesis of endothelial cells and inhibited proliferation of synovial cells. Taken together, these results implicated that baicalein might be an effective medicine for treating OA by regulating multiple targets.
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