Titanium Radical Redox Catalysis: Recent Innovations in Catalysts, Reactions, and Modes of Activation.
Titanium Radical Redox Catalysis: Recent Innovations in Catalysts, Reactions, and Modes of Activation.
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DOI：
10.1016/j.chempr.2022.06.005
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发表时间：
2022-07-14
期刊：
影响因子：
23.5
通讯作者：
Lin, Song
中科院分区：
文献类型：
--
作者：
Wu, Xiangyu;Chang, Yejin;Lin, Song
自由基化学已成为现代有机合成的基石，为化学家提供了许多新的工具，以迅速扩大学术和工业研究中的反应性和化学空间。在这方面，钛配合物已被认为是一类有吸引力的催化剂，由于其丰富的氧化还原活性，除了丰富和低毒性的这种早期过渡金属。传统上用于活化环氧化物和羰基化合物，钛自由基氧化还原催化近年来已进入新的领域，产生了各种有用的转换。在这个角度来看，我们强调最近的事态发展，在该地区的TiIII/IV催化方面的不同类型的化学键的激活。此外，我们讨论了未来的机会，在整合钛自由基化学与其他催化系统，以及与新兴的新技术，如光化学和电化学。自由基化学已成为现代有机合成的基石，使化学家能够迅速扩大反应性和化学空间。钛配合物由于其丰富的氧化还原活性、丰富的资源和低毒性而被认为是一种有吸引力的催化剂。在这个角度来看，我们强调了最近的发展，在TiIII/IV催化方面的不同类型的化学键的激活。此外，我们讨论了未来的机会，在整合钛自由基化学与其他催化系统，以及与新兴的新技术。
Radical chemistry has emerged as a cornerstone in modern organic synthesis, providing chemists with numerous new tools to rapidly expand reactivity and chemical space in academic and industrial research. In this regard, titanium complexes have been recognized as an attractive class of catalysts owing to their rich redox activities in addition to the abundance and low toxicity of this early transition metal. Traditionally employed for the activation of epoxides and carbonyl compounds, Ti radical redox catalysis has broken into new grounds in recent years, giving rise to a diverse repertoire of useful transformations. In this Perspective, we highlight recent developments in the area of TiIII/IV catalysis with respect to the activation of different types of chemical bonds. Furthermore, we discuss future opportunities in integrating Ti radical chemistry with other catalytic systems as well as with emerging new technologies such as photochemistry and electrochemistry. Radical chemistry has emerged as a cornerstone in modern organic synthesis, enabling chemists to rapidly expand reactivity and chemical space. Titanium complexes have been recognized as attractive catalysts owing to their rich redox activities, abundance, and low toxicity. In this Perspective, we highlight recent developments in TiIII/IV catalysis with respect to the activation of different types of chemical bonds. Furthermore, we discuss future opportunities in integrating Ti radical chemistry with other catalytic systems as well as with emerging new technologies.
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