Total body irradiation followed by bone marrow transplantation: comparison of once-daily and twice-daily fractionation regimens
Total body irradiation followed by bone marrow transplantation: comparison of once-daily and twice-daily fractionation regimens
复制标题
全身照射后进行骨髓移植：每日一次和每日两次分割方案的比较
作者：
T. Soejima;S. Hirota;K. Tsujino;E. Yoden;O. Fujii;Y. Ichimiya;I. Mizuno
目的本研究的目的是评估两种连续全身照射（TBI）方案的结果，特别关注肺部并发症。材料和方法对接受TBI随后骨髓移植的恶性疾病患者进行回顾性分析。患者86例（男性51例，女性35例）。共有 36 名患者接受了每日两次 2Gy 剂量的治疗，持续 3 天，总计 12Gy（A 组）。另外50名患者接受每日一次2.4或3.0Gy剂量治疗，持续4或5天，总计12Gy（B组）。结果5年总生存率为49.2%，无复发生存率为44.3%。两组之间的总生存期（P = 0.1237）或无复发生存期（P = 0.1548）没有显着差异。与 B 组的 3 名患者相比，A 组中有 2 名患者患有 3 级或以上的间质性肺炎。A 组患者（5 年概率为 7.6%）和 B 组患者（5 年概率为 13.9%）之间没有显着差异（P = 0.9519）。结论我们得出的结论是，我们的每日一次 TBI 方案是可行的，并且有利于降低 TBI 的复杂性。我们认为需要对 TBI 治疗方案进行进一步研究。
PurposeThe purpose of this study was to evaluate the results of two sequential total body irradiation (TBI) regimens, especially focusing on pulmonary complications.Materials and methodsPatients with malignant disease who underwent TBI followed by bone marrow transplantation were retrospectively reviewed. There were 86 patients (51 males, 35 females). Altogether, 36 patients were treated on twice-daily fractions of 2 Gy for 3 days to a total 12 Gy (group A). Another 50 patients were treated on once-daily fractions of 2.4 or 3.0 Gy for 4 or 5 days to a total 12 Gy (group B).ResultsThe 5-year overall survival rate was 49.2%, and relapse-free survival was 44.3%. There were no significant differences between the two groups regarding overall survival (P = 0.1237) or relapse-free survival (P = 0.1548). Two patients in group A had interstitial pneumonitis of grade 3 or higher severity compared with three patients in group B. There was no significant difference between patients in group A (5-year probability rate was 7.6%) and patients in group B (5-year probability rate was 13.9%) (P = 0.9519).ConclusionWe concluded that our once-daily TBI regimen is feasible and had the benefit of reducing the complexity of TBI. We believe that further investigation of the TBI regimen is needed.
全身照射依托泊苷与白消安-环磷酰胺作为未达到首次缓解的白血病患者骨髓移植准备方案的前瞻性随机比较：西南肿瘤组研究。
影响因子：
20.3
作者：
Blume,KG;Kopecky,KJ;Henslee-Downey,JP;Forman,SJ;Stiff,PJ;LeMaistre,CF;Appelbaum,FR
通讯作者：
Appelbaum,FR
全身照射总剂量、分次、剂量率和分布对骨髓移植的影响。
影响因子：
4
作者：
Appelbaum,FR
通讯作者：
Appelbaum,FR
首次缓解期急性髓系白血病患者的同种异体骨髓移植：两种照射方案的随机试验。
影响因子：
20.3
作者：
Clift,RA;Buckner,CD;Appelbaum,FR;Bearman,SI;Petersen,FB;Fisher,LD;Anasetti,C;Beatty,P;Bensinger,WI;Doney,K
通讯作者：
Doney,K