Neurobehavioral evaluation of rhesus monkey infants fed cow's milk formula, soy formula, or soy formula with added manganese
Neurobehavioral evaluation of rhesus monkey infants fed cow's milk formula, soy formula, or soy formula with added manganese
复制标题
DOI：
10.1016/j.ntt.2005.04.003
复制
发表时间：
2005-07-01
影响因子：
2.9
通讯作者：
Lonnerdal, B
中科院分区：
文献类型：
--
作者：
Golub, MS;Hogrefe, CE;Lonnerdal, B
研究了大豆配方奶粉中过量锰对神经行为的影响。雄性恒河猴(每组8只)从出生到4个月龄，饲喂以商品牛奶为基础的配方奶(对照)、以商品大豆蛋白为基础的配方奶(大豆)或添加锰的大豆配方奶(大豆+锰)。大豆配方奶粉的锰含量自然高于牛奶配方奶粉。猴子从出生到18个月大，接受了行为评估、生长测量和脑脊液(CSF)采样。Soy和Soy+Mn群体在社会二元互动中参与较少的游戏行为和更多的从属依恋。与对照组相比，这些组的觉醒周期和白天不活动的时间也更短。冲动测试对大豆群体饮食很敏感。大豆+锰组对多巴胺激动剂阿朴吗啡也有迟钝的反应。两组在脑脊液中的多巴胺和5-羟色胺代谢物浓度没有显著差异，但这些浓度与实验配方影响的几项任务相关。这项实验表明，大豆配方中的成分，包括锰，可能会影响大脑发育，这反映在行为测量上。(C)2005年爱思唯尔爱思唯尔。版权所有。
The possible neurobehavioral effects of excess manganese in soy formula were studied. Male rhesus monkeys (it =8/group) were fed a commercial cow's milk based formula (Control), a commercial soy protein based formula (Soy), or the soy formula with added manganese (Soy+Mn) from birth to 4 months of age. Soy formulas naturally have higher manganese (Mn) content than cow's milk formulas. Monkeys received behavioral evaluations, growth measurements, and cerebrospinal fluid (CSF) sampling from birth to 18 months of age. Soy and Soy+Mn groups engaged in less play behavior and more affiliative clinging in social dyadic interactions. These groups also had shorter wake cycles and shorter periods of daytime inactivity than controls. An impulsivity test was sensitive to the Soy group diet. The Soy+Mn group also had a blunted response to the dopamine agonist apomorphine. Groups did not differ significantly in CSF dopamine and serotonin metabolite concentrations, but these concentrations were correlated with several tasks affected by experimental formula. This experiment suggests that components of soy formula, including Mn, may influence brain development as reflected in behavioral measures. (c) 2005 Elsevier Ire. All rights reserved.