Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits
Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits
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DOI：
10.1538/expanim.14-0064
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发表时间：
2015-01-01
影响因子：
2.4
通讯作者：
Shao, Yi-Xiang
中科院分区：
文献类型：
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作者：
Liu, Chun;Wang, Sheng-Jie;Shao, Yi-Xiang
长期以来，饲喂药物一直被用来预防球虫病，这是一种世界性的原虫疾病。氟苯尼考(FFC)已广泛应用于兽医临床治疗细菌性疾病。因此，球虫药与FFC在兔体内的联合使用是很常见的。本研究旨在评价磺胺喹恶啉(Sul)、罗宾定(Rob)和托曲珠利(TOL)三种抗球虫药作为饲料添加剂对FFC在兔体内药动学的影响。本文研究了兔静脉注射FFC(25 mg/kg)20天后，分别饲喂含Sul(250ppm)、Rob(66ppnn)和Tol(2ppm)的无球虫饲料和饲料后的药物动力学。用高效液相色谱法测定血浆FFC浓度。采用基于统计矩理论的非房室分析方法，对FFC的药代动力学参数进行了分析。结果表明，与无抗球虫饲料相比，Rob饲料可显著降低血浆FFC水平。罗布给药后兔的终末消除半衰期(t(1/2z))、血药浓度时间曲线下面积(AUC)、一阶矩曲线下面积(AUMC)和平均停留时间(MR7)显著降低，消除速率常数(lambda(Z))和整体清除(CLz)明显增加。然而，我们没有发现SUL或TOL喂养对FFC的药代动力学曲线有任何影响。我们的研究结果表明，FFC在补充ROB的兔中的应用应引起更多的关注。
In-feed Medication has been used for a long time to prevent coccidiosis, a worldwide protozoal disease in rabbits. Florfenicol (FFC) has been widely used in veterinary clinics for bacterial diseases treatment. Therefore, the use of combinations of coccidiostats with FFC in rabbits is common. In the present study, we aimed to evaluate the effect of three coccidiostats, sulfaquinoxaline (SUL), robenidine (ROB), and toltrazuril (TOL), as feed additives on the pharmacokinetic profile of FFC in rabbits. The disposition kinetics of FFC in rabbits were investigated after a single intravenous injection (25 mg/kg) in rabbits fed anticoccidial-free diets or feeds containing SUL (250 ppm), ROB (66 ppnn), or TOL (2 ppm), respectively, for 20 days. Plasma FFC concentrations were determined by the high performance liquid chromatography (HPLC) method. The pharmacokinetic parameters of FFC were analyzed using a non-compartmental analysis based on the statistical moment theory. The results demonstrated that ROB feeding resulted in an obvious decrease in plasma FFC level as compared with anticoccidial-free feeding. The terminal elimination half-life (t(1/2z)), area under the concentration time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MR7) significantly decreased, whereas the elimination rate constant (lambda(z)) and total body clearance (CLz) obviously increased in rabbits pretreated with ROB. However, we did not find that SUL or TOL feeding had any effect on the pharmacokinetic profile of FFC. Our findings suggested that more attention should be paid to the use of FFC in rabbits supplemented with ROB.