Neutron capture therapy with boron in the treatment of glioblastoma multiforme.
Neutron capture therapy with boron in the treatment of glioblastoma multiforme.
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硼中子俘获疗法治疗多形性胶质母细胞瘤。
DOI：
10.1007/978-1-4757-9567-7_81
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发表时间：
1954
期刊：
影响因子：
--
通讯作者：
E. Stickley
中科院分区：
文献类型：
--
作者：
L. Farr;W. Sweet;J. Robertson;C. G. Foster;H. Locksley;D. L. Sutherland;M. Mendelsohn;E. Stickley
自1990年以来，我们根据Hatanaka的程序使用BSH通过BNCT治疗了14例胶质母细胞瘤患者。然而，在我们的早期患者中，几乎都是晚期病例，没有获得良好的临床结果，可能是因为我们BNCT受试者的10b浓度的肿瘤与血液之比分别低于1和/或在lOppm左右，大大低于预期值。在我们最近的研究对象中，假设T/B比值为1.0，BNCT期间血液中10b浓度维持在30ppm左右，以达到肿瘤中10b浓度28ppm的理论最低要求。这种策略改善了胶质母细胞瘤患者bnct后的病程。据报道，在胶质母细胞瘤患者和脑肿瘤动物模型中，BSH的T/B比率都有很大的差异（1,2,3）。为了估计BSH的最佳剂量，我们之前研究了BSH在新诊断的受试者和脑瘤动物的肿瘤和血液中的定量分布。在本研究中，我们通过提示伽马射线能谱（PGS）和α-径迹刻蚀法（ATM）研究了BSH在新诊断的人类胶质母细胞瘤患者中的定量分布，并探讨了其在临床中的有效性。
Since 1990, we have treated fourteen glioblastoma patients by BNCT using BSH according to Hatanaka’s procedures. However, in our early patients, who were almost all advanced cases, good clinical results were not obtained, probably because the tumor to blood ratio of10B concentration in our BNCT subjects was always under 1 and/or around lOppm, respectively, considerably lower than the expected values. In our recent subjects, assuming the T/B ratio to be 1.0, the10B concentration in blood was maintained at around 30ppm during BNCT to achieve a10B concentration in the tumor of 28ppm, the theoretically required minimum concentration. This strategy improved the post-BNCT course in glioblastoma patients. In both glioblastoma patients and brain tumor animals models, the T/B ratio of BSH has been reported to show wide variations (l, 2, 3). To estimate the optimal dosage of BSH, we have previously investigated the quantitative distribution of BSH in tumors and blood in newly diagnosed subjects and in brain tumor-bearing animals. In this study, we investigated the quantitative distribution of BSH via prompt gamma ray spectroscopy (PGS) and an α-track etch method (ATM) in newly diagnosed human glioblastoma patients and its effectiveness was discussed for the clinical purpose.