Gene-diet interactions in obesity
Gene-diet interactions in obesity
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DOI：
10.1093/ajcn/72.5.1285s
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发表时间：
2000-11-01
影响因子：
7.1
通讯作者：
Bouchard, C
中科院分区：
文献类型：
--
作者：
Perusse, L;Bouchard, C
在过去的几年里，关于肥胖的遗传学研究已经有了相当多的报道。尽管有证据表明遗传因素在这种营养性疾病的病因学中起着重要作用，并且越来越多的肥胖基因被发现，但对于基因在肥胖表型对能量平衡或饮食组成改变的反应中所起的作用，我们所知相对较少。对于膳食脂肪来说尤其如此，众所周知，膳食脂肪与人口肥胖有关。这篇综述的目的是总结目前关于基因-营养相互作用在人类肥胖中的作用的证据。来自遗传流行病学和分子流行病学研究的证据表明，遗传因素参与决定饮食对脂肪增加或减少的易感性，或在肥胖个体中普遍观察到的一些合并症的发生风险。最近的证据表明，从饮食引起的肥胖动物模型中发现的数量性状位点可能影响人类的体脂。尽管研究数量有限，但肥胖中基因-饮食相互作用的证据是令人信服的。需要更多的研究来确定导致这些相互作用的基因，使用饮食引起的肥胖的动物模型代表了一种很有前途的方法。最后，需要关于儿童的数据，以便对儿童和成年之间的营养摄入跟踪进行评估。此外，还需要研究儿童的基因-饮食相互作用，以确定所涉及的基因是否与成人的基因相同。
A considerable amount of research on the genetics of obesity has been reported in the past few years. Despite evidence that genetic factors play a significant role in the etiology of this nutritional disease and the increasing number of obesity genes identified, relatively little is known about the role of genes in the response of obesity phenotypes to alterations in energy balance or diet composition. This is especially true for dietary fat, which is known to be associated with obesity at the population level. The aim of this review was to summarize the evidence currently available about the role of gene-nutrient interactions in human obesity. Evidence from both genetic epidemiology and molecular epidemiology studies suggests that genetic factors are involved in determining the susceptibility to gaining or losing fat in response to diet or the risk of developing some of the comorbidities generally observed in obese individuals. Recent evidence suggests that quantitative trait loci identified from animal models of diet-induced obesity could influence body fat in humans. Despite the limited number of studies, the evidence on gene-diet interactions in obesity is convincing. More research is needed to identify the genes responsible for these interaction effects, and the use of animal models of diet-induced obesity represents a promising approach. Finally, data on children are needed to allow assessment of the tracking of nutrient intake between childhood and adulthood. In addition, gene-diet interactions in children need to be investigated to determine whether the genes involved are the same as those found in adults.