History of conditioned reward association disrupts inhibitory control: an examination of neural correlates.
History of conditioned reward association disrupts inhibitory control: an examination of neural correlates.
复制标题
条件奖励关联的历史破坏了抑制控制：神经相关性的检查。
DOI：
10.1016/j.neuroimage.2020.117629
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发表时间：
2021
期刊：
影响因子：
5.7
通讯作者：
Sheridan,MargaretA
中科院分区：
文献类型：
--
作者：
Meyer,KristinN;Davidow,JulietY;VanDijk,KoeneRA;Santillana,RosarioM;Snyder,Jenna;Bustamante,ConstanzaMVidal;Hollinshead,Marissa;Rosen,BruceR;Somerville,LeahH;Sheridan,MargaretA
在面对具有奖励关联历史的刺激时，支持抑制控制的神经过程尚未得到很好的理解。然而，灵活地调整行为以适应不断变化的奖励-应急环境的能力对日常运作很重要，值得进一步研究。本研究的目的是通过调查群体水平的影响，以及个体的差异，抑制反应的能力，以奖励历史的刺激与运动抑制控制的条件性奖励协会的历史，在健康的年轻人的神经和行为的影响。参与者（N = 41）首先完成了奖励条件反射阶段，在此期间，对奖励刺激的反应与金钱有关，而对非奖励刺激的反应则与金钱无关。奖励和未奖励的刺激，从培训结转作为No-Go的目标，在随后的去/不去任务，以测试抑制控制的奖励历史的影响。参与者在任务的进行/不进行部分进行了功能性脑成像。平均而言，奖励条件反射的历史破坏了抑制控制。与抑制对无奖励史刺激的反应相比，要求抑制对先前奖励刺激的反应的试验与额叶和纹状体区域的更大活动相关，包括额下回，纹状体，纹状体和丘脑。在错误警报期间，丘脑和丘脑的活动，以及在正确保留试验期间，腹内侧前额叶皮层的活动，预测了任务的行为表现。总体而言，这些结果表明，奖励的历史，以破坏抑制控制，并提供证据，不同的角色的大脑皮层和腹内侧前额叶皮层，同时抑制反应的刺激与奖励的历史。
The neural processes that support inhibitory control in the face of stimuli with a history of reward association are not yet well understood. Yet, the ability to flexibly adapt behavior to changing reward-contingency contexts is important for daily functioning and warrants further investigation. This study aimed to characterize neural and behavioral impacts of stimuli with a history of conditioned reward association on motor inhibitory control in healthy young adults by investigating group-level effects as well as individual variation in the ability to inhibit responses to stimuli with a reward history. Participants (N = 41) first completed a reward conditioning phase, during which responses to rewarded stimuli were associated with money and responses to unrewarded stimuli were not. Rewarded and unrewarded stimuli from training were carried forward as No-Go targets in a subsequent go/no-go task to test the effect of reward history on inhibitory control. Participants underwent functional brain imaging during the go/no-go portion of the task. On average, a history of reward conditioning disrupted inhibitory control. Compared to inhibition of responses to stimuli with no reward history, trials that required inhibition of responses to previously rewarded stimuli were associated with greater activity in frontal and striatal regions, including the inferior frontal gyrus, insula, striatum, and thalamus. Activity in the insula and thalamus during false alarms and in the ventromedial prefrontal cortex during correctly withheld trials predicted behavioral performance on the task. Overall, these results suggest that reward history serves to disrupt inhibitory control and provide evidence for diverging roles of the insula and ventromedial prefrontal cortex while inhibiting responses to stimuli with a reward history.