Human Papillomavirus and Survival of Sinonasal Squamous Cell Carcinoma Patients: A Systematic Review and Meta-Analysis.
Human Papillomavirus and Survival of Sinonasal Squamous Cell Carcinoma Patients: A Systematic Review and Meta-Analysis.
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DOI：
10.3390/cancers13153677
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发表时间：
2021-07-22
期刊：
影响因子：
5.2
通讯作者：
Langevin SM
中科院分区：
文献类型：
--
作者：
Sharma A;Tang AL;Takiar V;Wise-Draper TM;Langevin SM
人乳头瘤病毒（HPV）与肛门生殖器和上呼吸消化道的多种癌症有关。在头颈部，HPV阳性癌症在口咽部很常见，发病率不断上升，并且与更有利的患者结局有着良好的关联。然而，鼻窦鳞状细胞癌（SNSCC）与预后的关系很少被研究，目前尚不清楚。为了更好地阐明这种关系，我们对生物医学文献进行了系统回顾和荟萃分析，以确定研究之间的总体效应。在这样做的过程中，我们观察到HPV阳性SNSCC的总生存率显著提高。因此，我们得出结论，HPV检测可能有助于确定患者预后，并可能指导治疗决策。 人乳头瘤病毒（HPV）在鼻腔鼻窦鳞状细胞癌（SNSCC）的一个子集中是可检测的，但由于统计功效有限的研究数量有限，目前对患者结局的影响尚不清楚。因此，我们进行了系统性综述和荟萃分析，以更好地阐明这种关系。进行PubMed检索，以确定所有报告HPV状态的SNSCC总体（OS）或无病生存期（DFS）的研究。提取风险比（HR）和相应的95%置信区间（CI），或者在未提供时，从每份手稿中间接估计。根据研究特定Kaplan-Meier曲线，5年OS的生存曲线总结和根据预先规定的时间间隔的HPV状态估计生存概率，生成2年DFS。合并研究间的Log HR和log CI，以生成OS和DFS的汇总估计值和相应的95% CI。我们确定了10项关于OS的独特研究和4项关于DFS的独特研究。我们观察到HPV与OS之间存在显著相关性（汇总HR = 0.51，95% CI：0.38-0.70），研究间异质性相对较低。这些结果表明，HPV是SNSCC更有利生存的重要预测因子，因此可能是一种有用的生物标志物，用于预测和潜在的治疗调节。
Human papillomavirus (HPV) has been associated with multiple cancers in the anogenital and upper aerodigestive tracts. In the head and neck region, HPV-positive cancers are common in oropharynx, with rising incidence and a well-established association with more favorable patient outcomes. However, the relationship with prognosis of sinonasal squamous cell carcinoma (SNSCC) has been much less often studied and is presently unclear. To better elucidate this relationship, we performed a systematic review and meta-analysis of the biomedical literature to determine the aggregate effect across studies. In doing so, we observed significantly better overall survival associated with HPV-positive SNSCC. Therefore, we conclude that HPV testing may be useful for determining patient prognosis and potentially guiding treatment decisions. Human papillomavirus (HPV) is detectable in a subset of sinonasal squamous cell carcinoma (SNSCC), but the impact on patient outcomes is presently unclear due to a modest number of studies with limited statistical power. Therefore, we conducted a systematic review and meta-analysis to better clarify this relationship. A PubMed search was conducted to identify all studies reporting on overall (OS) or disease-free survival (DFS) for SNSCC by HPV status. Hazard ratios (HR) and corresponding 95% confidence intervals (CI) were extracted or, when not provided, indirectly estimated from each manuscript. Summary survival curves for 5-year OS and estimating survival probability by HPV status at pre-specified time intervals from study-specific Kaplan-Meier curves generated 2-year DFS. Log HRs and log CIs were combined across studies to generate summary estimates and a corresponding 95% CIs for OS and DFS. We identified ten unique studies reporting on OS and four for DFS. We observed a significant association between HPV and OS (summary HR = 0.51, 95% CI: 0.38–0.70) with relatively low heterogeneity between studies. These results indicate that HPV is a significant predictor of more favorable survival for SNSCC, and thus may be a useful biomarker for prognostication and, potentially, treatment modulation.
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影响因子：
45.3
作者：
Fakhry, Carole;Lacchetti, Christina;Perez-Ordonez, Bayardo
通讯作者：
Perez-Ordonez, Bayardo
影响因子：
4.8
作者：
D'Souza G;Anantharaman D;Gheit T;Abedi-Ardekani B;Beachler DC;Conway DI;Olshan AF;Wunsch-Filho V;Toporcov TN;Ahrens W;Wisniewski K;Merletti F;Boccia S;Tajara EH;Zevallos JP;Levi JE;Weissler MC;Wright S;Scelo G;Mazul AL;Tommasino M;Cadoni G;Brennan P
通讯作者：
Brennan P
DOI：
10.1007/s00432-017-2481-8
发表时间：
2017-11-01
影响因子：
3.6
作者：
Ko, Huaising C.;Harari, Paul M.;Witek, Matthew E.
通讯作者：
Witek, Matthew E.
影响因子：
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作者：
Bland, JM;Altman, DG
通讯作者：
Altman, DG
影响因子：
2.6
作者：
Haerle, Stephan K.;Gullane, Patrick J.;Gentili, Fred
通讯作者：
Gentili, Fred