Limited knowledge and use of HIV post- and pre-exposure prophylaxis among gay and bisexual men
Limited knowledge and use of HIV post- and pre-exposure prophylaxis among gay and bisexual men
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DOI：
10.1097/qai.0b013e31815e4041
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发表时间：
2008-02-01
影响因子：
3.6
通讯作者：
Buchbinder, Susan P.
中科院分区：
文献类型：
--
作者：
Liu, Albert Y.;Kittredge, Pravina V.;Buchbinder, Susan P.
工作背景：目前建议在某些高风险暴露后进行暴露后预防（PEP），而暴露前预防（PrEP）正在临床试验中进行评估。媒体报道表明，尽管PrEP的有效性未经证实，但社区PrEP的使用水平仍很高。方法：我们对加州1819名未感染艾滋病毒的同性恋/双性恋男性进行了一项横断面调查，以评估PEP和PrEP的意识和使用情况。结果：总体而言，47%的人表示了解PEP，4%的人曾使用过PEP。25岁以上的男性（比值比[OR] = 2.2，95%置信区间[CI]：1.5 - 3.1），为白色（OR = 2.2，95%CI：1.6 - 3.0），年收入> 10万美元（OR = 2.0，95%CI：1.2至3.4），自我认同为同性恋/同性恋（OR = 2.4，95% CI：1.4 - 4.3），并且有无保护的肛交（OR 1.8，95% CI：1.3 - 2.3）或受药物影响的性别（OR 2.0，95% CI：1.5至2.7）更有可能意识到PEP，而速度用户（OR = 0.6，95% CI：0.4至0.9）不太可能意识到PEP。只有16%的人报告了PrEP意识，<1%的人曾经使用过PrEP。无保护的肛交（OR = 1.6，95% CI：1.1至2.3）和药物影响下的性行为（OR = 1.5，95% CI：1.0至2.2）与PrEP意识有关。结论：PEP意识和使用是适度的，PrEP使用在加州的男同性恋/双性恋男性中很少见。虽然目前不建议使用PrEP，但建议对PEP的可用性进行社区教育。
Background: Post-exposure prophylaxis (PEP) is currently recommended after certain high-risk exposures, and pre-exposure prophylaxis (PrEP) is undergoing evaluation in clinical trials. Media reports have suggested substantial levels of community PrEP use despite its unproven effectiveness.Methods: We conducted a cross-sectional survey of 1819 HIV- uninfected gay/bisexual men in California to assess PEP and PrEP awareness and use.Results: Overall, 47% reported PEP awareness and 4% ever used PEP. Men who were older than 25 years of age (odds ratio [OR] = 2.2, 95% confidence interval [CI]: 1.5 to 3.1), were white (OR = 2.2, 95% CI: 1.6 to 3.0), had an annual income >$ 100,000 (OR = 2.0, 95% CI: 1.2 to 3.4), self-identified as gay/homosexual (OR = 2.4, 95% CI: 1.4 to 4.3), and had unprotected anal sex (OR 1.8, 95% CI: 1.3 to 2.3) or sex under the influence of a drug (OR 2.0, 95% CI: 1.5 to 2.7) were more likely to be aware of PEP, whereas speed users (OR = 0.6, 95% CI: 0.4 to 0.9) were less likely to be aware of PEP. Only 16% reported PrEP awareness, and < 1 % ever used PrEP. Unprotected anal sex (OR = 1.6, 95% CI: 1.1 to 2.3) and sex under the influence of a drug (OR = 1.5, 95% CI: 1.0 to 2.2) were associated with PrEP awareness.Conclusions: PEP awareness and use were modest and PrEP use was rare among gay/bisexual men in California. Although PrEP is not currently recommended, community education on the availability of PEP is suggested.