Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo.
Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo.
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Zn(II) 自组装体对体外和卵内癌细胞具有选择性细胞毒活性的临床前评估。
DOI：
10.1002/chem.202302803
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Allison SJ
中科院分区：
文献类型：
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作者：
Allison SJ
二足吡啶基噻唑胺配体L1和L2都与锌、铜形成了不同的金属超分子自组装，在体外 实验中，它们对癌细胞具有毒性和选择性。此外，活性和选择性高度依赖于金属离子、配体系统和结合阴离子，化学敏感性和选择性的显著变化取决于所使用的物种。重要的是，在无毒的卵子剂量中观察到了显著的抗肿瘤活性。
Dipodal pyridylthiazole amine ligandsL1andL2both form different metallo‐supramolecular self‐assemblies with Zn2+and Cu2+and these are shown to be toxic and selective towards cancer cell lines in vitro. Furthermore, potency and selectivity are highly dependent upon the metal ions, ligand system and bound anion, with significant changes in chemosensitivity and selectivity dependent upon which species are employed. Importantly, significant anti‐tumor activity was observedin ovoat doses that are non‐toxic.